aminopterin


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aminopterin:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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aminopterin

[‚a·mə′näp·tə·rən]
(pharmacology)
C19H20N8O5·2H2O A yellow crystalline acid which is similar to folic acid and is used clinically as an antagonist of folic acid.
References in periodicals archive ?
Likewise dihydroreductase inhibitors, e.g., sulfasalazine, methotrexate, triamterene, and aminopterin, that block conversion of folate to its more active metabolites, are known to cause NTDs.
These drugs include aminopterin sulfasalazine, pyrimethamine, triamterene, trimethoprim, and methotrexate (N.
These drugs include aminopterin, sulfasalazine, pyrimethamine, triamterene, trimethoprim, and methotrexate, they reported (N.
During the 1940s childhood leukemias had a uniformly rapid fatal course over a short period of time, thus the designation of the term "acute."[5] In the late 1940s, Farber and colleagues[6] found that aminopterin (a folic acid antagonist) could induce temporary remissions in leukemia.
* aminopterin in Phase II in patients with persistent, recurrent or refractory endometrial carcinoma
Here's why: n A drug that prevents the body from using folic acid (aminopterin) causes NTDS in mice, cats, and rats.
The human vascular endothelial cell line (EA.hy926) was grown in DMEM supplemented with 15% FBS, HAT (100 mM sodium hypoxanthine, 0.4 mM aminopterin, and 16 mM thymidine), 1% glutamine, and 1% penicillin-streptomycin-neomycin at 37[degrees]C in a 5% C[O.sub.2] humidified incubator.
Good examples of vitamin antagonists include isonicotinic acid hydrazide (antagonist of pyridoxine), aminopterin (folate antagonist), dicumarol (vitamin K antagonist), and avidin (interferes with biotin absorption).
wheat gluten contaminated with aminopterin, a toxin used in some countries as rat poison.
The federal government prohibits using aminopterin for killing rodents in the United States.
* In utero exposure to aminopterin, an antagonist of folic acid, has been associated with anencephaly, meningocele, hydrocephalus, and cleft lip and palate (Thiersch 1952; Warkany et al.