aminopterin


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aminopterin:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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aminopterin

[‚a·mə′näp·tə·rən]
(pharmacology)
C19H20N8O5·2H2O A yellow crystalline acid which is similar to folic acid and is used clinically as an antagonist of folic acid.
References in periodicals archive ?
Scientists at the New York State Animal Health Diagnostic Center at Cornell University and at the New York State Food Laboratory tested three cat food samples provided by the manufacturer and found aminopterin in two of them.
We became concerned when Aminopterin was implicated as the toxin in the recent pet food recall.
Using a highly specific and sensitive test for Aminopterin, investigators at UMDNJ documented that there was no evidence of Aminopterin in the tissues of affected animals.
The reference to the use of Aminopterin as a rodenticide (i.
Kamen with grants for the clinical testing of Aminopterin in pediatric leukemia.
acquired the exclusive rights to Aminopterin from UMDNJ in February 2003.
In a Phase I trial of aminopterin among patients with a variety of such refractory cancers completed last year, Dr.
NASDAQ: ILXO) today announced the initiation of a Phase II trial of aminopterin, a potent antifolate that effectively inhibits cancer cell replication.
Splenocytes were fused with a nonsecretor cell line sp2/0 and plated into Dulbecco's modified Eagle's medium containing hypoxanthine, aminopterin, and thymidine with 150 mL/L fetal bovine serum.
Researchers at the University of Texas Southwestern Medical Center at Dallas received a three-year grant to begin Phase II clinical trials of the ILEX compound, Aminopterin.
With regard to our products, we are particularly pleased with the progress being made on Campath, Piritrexim, DFMO and Aminopterin, all of which are in advanced clinical trials.
4 [micro]mol/L aminopterin, and 16 [micro]mol/L thymidine (Gibco BRL).