Aminopyrine N-demethylase (APD), Benzphetamine demethylase (BD) and N.N.
(1986) reported inhibition in the activities of aminopyrine N-demethylase and P-nitroanisole o-demethylase after mercury administration.
The FETAX system measures formaldehyde production from aminopyrine in tissues that have had cytochrome P-450 induced by a specific chemical (Bantle et al., 1990).
The reaction mixture consisting of 5 mM glucose-6-phosphate (126 [micro]l of 840 mM glucose-6-phosphate), 0.4 mM NADPH (3360 [micro]l of 2.5 mM NADPH), 20 mM magnesium chloride (178 [micro]l of 235 mM MgC[l.sub.2]), 8 mM Aminopyrine (3780 [micro]l of 10mM aminopyrine) and 10 units of glucose-6-phosphate dehydrogenase was mixed with 9129 [micro]l of buffer 1 in a 125 ml Erlenmeyer flask.
Individuals who are taking various prescription drugs, such as warfarin, antipyrine, diazepam,
aminopyrine, and cimetidine would be interested in knowing that studies reported in the book indicate an arrested metabolism of medication when caffeine is used simultaneously.
The Modified Nash Assay is a reliable metabolic system that measures the product of enzyme substrate/activity of Cytochrome-P-450 as a product of formalin from
Aminopyrine. For the first part of this experiment Xenopus embryos were grown in Fetax and collected at 24,48,72,96 hour intervals, and frozen until S-9 preparation.
The occurrence of 7-methyldeoxyguanosine (7-MedG) and [O.sup.6]-methyldeoxyguanosine ([O.sup.6]-MedG) was decreased in rat liver when garlic powder was added to a diet containing
aminopyrine and sodium nitrite (96).
This noninvasive test utilizes
aminopyrine, an agent eliminated via cytochrome P450 enzyme-catalyzed N-demethylation [77].
The
aminopyrine breath test has been investigated extensively as a simple and reliable index of hepatic microsomal enzyme reserve X10].
