aminopyrine


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aminopyrine

[ə′mē·nō′pī‚rēn]
(pharmacology)
C13H17N3O Leafletlike crystals with a melting point of 107-109°C; soluble in alcohol, benzene, and chloroform; used as an antipyretic and analgesic in humans and animals.
References in periodicals archive ?
Aminopyrine N-demethylase (APD), Benzphetamine demethylase (BD) and N.N.
(1986) reported inhibition in the activities of aminopyrine N-demethylase and P-nitroanisole o-demethylase after mercury administration.
The FETAX system measures formaldehyde production from aminopyrine in tissues that have had cytochrome P-450 induced by a specific chemical (Bantle et al., 1990).
The reaction mixture consisting of 5 mM glucose-6-phosphate (126 [micro]l of 840 mM glucose-6-phosphate), 0.4 mM NADPH (3360 [micro]l of 2.5 mM NADPH), 20 mM magnesium chloride (178 [micro]l of 235 mM MgC[l.sub.2]), 8 mM Aminopyrine (3780 [micro]l of 10mM aminopyrine) and 10 units of glucose-6-phosphate dehydrogenase was mixed with 9129 [micro]l of buffer 1 in a 125 ml Erlenmeyer flask.
Individuals who are taking various prescription drugs, such as warfarin, antipyrine, diazepam, aminopyrine, and cimetidine would be interested in knowing that studies reported in the book indicate an arrested metabolism of medication when caffeine is used simultaneously.
The Modified Nash Assay is a reliable metabolic system that measures the product of enzyme substrate/activity of Cytochrome-P-450 as a product of formalin from Aminopyrine. For the first part of this experiment Xenopus embryos were grown in Fetax and collected at 24,48,72,96 hour intervals, and frozen until S-9 preparation.
The occurrence of 7-methyldeoxyguanosine (7-MedG) and [O.sup.6]-methyldeoxyguanosine ([O.sup.6]-MedG) was decreased in rat liver when garlic powder was added to a diet containing aminopyrine and sodium nitrite (96).
This noninvasive test utilizes aminopyrine, an agent eliminated via cytochrome P450 enzyme-catalyzed N-demethylation [77].
The aminopyrine breath test has been investigated extensively as a simple and reliable index of hepatic microsomal enzyme reserve X10].