Aminopyrine N-demethylase (APD), Benzphetamine demethylase (BD) and N.N.
(1986) reported inhibition in the activities of aminopyrine N-demethylase and P-nitroanisole o-demethylase after mercury administration.
The FETAX system measures formaldehyde production from aminopyrine in tissues that have had cytochrome P-450 induced by a specific chemical (Bantle et al., 1990).
The reaction mixture consisting of 5 mM glucose-6-phosphate (126 [micro]l of 840 mM glucose-6-phosphate), 0.4 mM NADPH (3360 [micro]l of 2.5 mM NADPH), 20 mM magnesium chloride (178 [micro]l of 235 mM MgC[l.sub.2]), 8 mM Aminopyrine (3780 [micro]l of 10mM aminopyrine) and 10 units of glucose-6-phosphate dehydrogenase was mixed with 9129 [micro]l of buffer 1 in a 125 ml Erlenmeyer flask.
Individuals who are taking various prescription drugs, such as warfarin, antipyrine, diazepam, aminopyrine
, and cimetidine would be interested in knowing that studies reported in the book indicate an arrested metabolism of medication when caffeine is used simultaneously.
The Modified Nash Assay is a reliable metabolic system that measures the product of enzyme substrate/activity of Cytochrome-P-450 as a product of formalin from Aminopyrine
. For the first part of this experiment Xenopus embryos were grown in Fetax and collected at 24,48,72,96 hour intervals, and frozen until S-9 preparation.
The occurrence of 7-methyldeoxyguanosine (7-MedG) and [O.sup.6]-methyldeoxyguanosine ([O.sup.6]-MedG) was decreased in rat liver when garlic powder was added to a diet containing aminopyrine
and sodium nitrite (96).
This noninvasive test utilizes aminopyrine
, an agent eliminated via cytochrome P450 enzyme-catalyzed N-demethylation .
breath test has been investigated extensively as a simple and reliable index of hepatic microsomal enzyme reserve X10].