amodiaquine


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amodiaquine

[‚am·ō′dī·ə‚kwēn]
(pharmacology)
C20H22ClN3O A crystalline compound that melts at 208°C; used as an antimalarial.
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He said the children aged three months to 59 months would be administered with Sulfadoxine-Pyrimethamine plus amodiaquine, free of charge.
Interactions of the antimalarial amodiaquine with lipid model membranes.
However, our findings are further supported by the work of many investigators who reported hepatic damage due to increase in serum enzymes by administration of halofantrine (Obi et al., 2004), amodiaquine (Farombi, 2000), sulfadoxin epyrimethamine (Mishra et al., 2011) and chloroquine (Pari and Amali, 2005).
Amodiaquine, an anti-malarial compound, inhibits the growth of epithelial cancer cells in culture.
Mutations (N86Y, Y184F, S1034C, N1042D, and D1246Y) in the pfmdr1 gene have been associated with resistance to multiple antimalarial drugs such as quinine, mefloquine, halofantrine, artemisinin, lumefantrine, CQ, and amodiaquine [10-13].
falciparum to 4-aminoquinolines (chloroquine, amodiaquine), antifols, and dihydrofolate reductase inhibitors (pyrimethamine, proguanil) in many endemic regions [6] and the emergence of in vitro and in vivo resistance to aminoalcohols (quinine, mefloquine, and halofantrine) have been reported in some areas of Southeast Asia [7-9].
In the Republic of Congo, where malaria is still the leading cause of attendance in health facilities, the high level of resistance of Plasmodium falciparum to chloroquine and the inefficacy of sulphadoxine-pyrimethamine and amodiaquine either singly or in combination for the treatment of uncomplicated malaria have been well documented [2-5].
Following a period of continuous increase in resistance of Plasmodium falciparum against the commonly used antimalarial drugs such as chloroquine, and Sulphadoxine-Pyrimethamine (SP), the new artemisinin-based combination therapy (ACT) was introduced in 2005 with Artemether-Lumefantrine (AL) as first-line treatment for uncomplicated malaria and Artesunate + Amodiaquine (copackaged) as alternative [3, 4].
Currently, treatment for malaria combines rapidly-acting artemisinins with lumefantrine, amodiaquine, mefloquine and other antimalarials for durability.
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years.
falciparum (NF54), cryptolepine exhibited promising synergistic interactions in vitro with artesunate, artemether, dihydroartemisinin, and amodiaquine. The combination of cryptolepine with chloroquine and lumefantrine showed an additive effect, whereas antagonism was observed with mefloquine in an isobologram analysis.
CYP2C8 mediates the modification of several anticancer, antidiabetic, and antimalarial drugs, including paclitaxel, troglitazone, and amodiaquine [28].