amphotericin B


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Related to amphotericin B: liposomal amphotericin B

amphotericin B

(ăm'fətĕr`ĭsĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 that halts the growth of several disease-causing fungi. Discovered in 1956, it is produced by bacteria of the genus Streptomyces. It is used in lotion or ointment form to treat fungal infections of the skin and is given internally only to patients with potentially fatal fungal infections. Amphotericin B is not effective against bacterial infections.

amphotericin B

[‚am·fə′ter·ə·sən ′bē]
(microbiology)
C46H73O20N The active component of amphotericin, suitable for systemic therapy of deep or superficial mycotic infections.
References in periodicals archive ?
Six vials, each containing 50 mg of conventional non-lipid amphotericin B (Fungizone[R]), were available in each of the two ADCs in the ICU.
A clinical study comparing AmBisome to amphotericin B deoxycholate (Study 94-0-002) showed that AmBisome was well tolerated.
For the 25-mg dose, the peak systemic level of the drug was 20 ng/mL, which is about 2% of the level generally regarded as the threshold of toxicity for amphotericin B, Dr.
Because the most common fungal etiology of near drowning pneumonia is P boydii, an organism resistant to amphotericin B, bronchoscopy was performed to assess for a common pulmonary and cutaneous pathogen.
In a study conducted by researchers at the National Cancer Institute, the urinary pharmacokinetics and disposition of Nyotran(R) (2, 4 or 6 mg/kg) and amphotericin B (1 mg/kg) were investigated in normal rabbits.
In each dose group, twelve volunteers received a single dose of Bioral Amphotericin B and four received a placebo.
Azotemia, hypokalemia, and normocytic anemia were observed as adverse effects of the previous amphotericin B treatment.
The changing epidermiology of fungal infections: Are the lipid-forms of amphotericin B an advance?
Successful treatment of aspergillosis in liver transplant recipients should include early diagnosis, sequential medical treatment with lipid amphotericin B and itraconazole, and surgical intervention for invasive disease.