amphotericin B


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Related to amphotericin B: liposomal amphotericin B

amphotericin B

(ăm'fətĕr`ĭsĭn), antibioticantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 that halts the growth of several disease-causing fungi. Discovered in 1956, it is produced by bacteria of the genus Streptomyces. It is used in lotion or ointment form to treat fungal infections of the skin and is given internally only to patients with potentially fatal fungal infections. Amphotericin B is not effective against bacterial infections.

amphotericin B

[‚am·fə′ter·ə·sən ′bē]
(microbiology)
C46H73O20N The active component of amphotericin, suitable for systemic therapy of deep or superficial mycotic infections.
References in periodicals archive ?
Amphotericin B attains high concentrations in tissues like liver, spleen, and lungs.
Wiederhold, "Large-scale evaluation of in vitro amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S.
Group F received saline loading along with acute nephrotoxic regimen of cyclosporine, amphotericin B infusion given on 5th day.
All the isolates resistant to voriconazole were also resistant to amphotericin b and itraconazole.
Antifungal susceptibility showed higher resistance in NAC species which was statistically not significant except for amphotericin B which was significant (P < 0.05), and C.
Out of 7 isolates, Candida krusei showed sensitivity to Voriconazole, Caspofungin, Micafungin and Amphotericin B were 85% each, Flucytosine and Fluconazole were 15% each.
To evaluate the effect of simvastatin, amphotericin B, and itraconazole on growing biofilm, 100 [micro]L of the fungal suspension was exposed to 100 [micro]L of simvastatin and incubated at 35[degrees]C for 48 h.
A phase II randomized trial of amphotericin B alone or combined with fluconazole in the treatment of HIV-associated cryptococcal meningitis.
The mice were randomized into four groups of 8 mice each.Group A: Received 3.7 ml/kg of 5% dextrose solution intraperitoneally daily for 7 days.Group B: Received Amphotericin B at dosage of 18.5 mg/kg dissolved in 3.7 ml of 5% dextrose solution intraperitoneally daily for 7 days.Group C: Received Amphotericin B at dosage of 18.5 mg/kg dissolved in 3.7 ml of 5% dextrose solution intraperitoneally along with the extract of Nigella sativa500 mg/kg orally daily for 7 days.25
Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with amphotericin B or fluconazole.
The patient was started on liposomal amphotericin B at 5mg/kg intravenously daily, in addition to fluconazole 800 mg intravenously daily for two weeks.
The standard dosing for conventional amphotericin B (brand name Fungizone) is substantially lower than those for the lipid-based formulations (AmBisomc, a liposomal formulation, and Abclcct, a lipid complex formulation).