Amphotericin B attains high concentrations in tissues like liver, spleen, and lungs.
Wiederhold, "Large-scale evaluation of in vitro
amphotericin B, triazole, and echinocandin activity against Coccidioides species from U.S.
Group F received saline loading along with acute nephrotoxic regimen of cyclosporine,
amphotericin B infusion given on 5th day.
All the isolates resistant to voriconazole were also resistant to
amphotericin b and itraconazole.
Antifungal susceptibility showed higher resistance in NAC species which was statistically not significant except for
amphotericin B which was significant (P < 0.05), and C.
Out of 7 isolates, Candida krusei showed sensitivity to Voriconazole, Caspofungin, Micafungin and
Amphotericin B were 85% each, Flucytosine and Fluconazole were 15% each.
To evaluate the effect of simvastatin,
amphotericin B, and itraconazole on growing biofilm, 100 [micro]L of the fungal suspension was exposed to 100 [micro]L of simvastatin and incubated at 35[degrees]C for 48 h.
A phase II randomized trial of
amphotericin B alone or combined with fluconazole in the treatment of HIV-associated cryptococcal meningitis.
The mice were randomized into four groups of 8 mice each.Group A: Received 3.7 ml/kg of 5% dextrose solution intraperitoneally daily for 7 days.Group B: Received
Amphotericin B at dosage of 18.5 mg/kg dissolved in 3.7 ml of 5% dextrose solution intraperitoneally daily for 7 days.Group C: Received
Amphotericin B at dosage of 18.5 mg/kg dissolved in 3.7 ml of 5% dextrose solution intraperitoneally along with the extract of Nigella sativa500 mg/kg orally daily for 7 days.25
Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviral-naive or antiretroviral-experienced patients treated with
amphotericin B or fluconazole.
The patient was started on liposomal
amphotericin B at 5mg/kg intravenously daily, in addition to fluconazole 800 mg intravenously daily for two weeks.
The standard dosing for conventional
amphotericin B (brand name Fungizone) is substantially lower than those for the lipid-based formulations (AmBisomc, a liposomal formulation, and Abclcct, a lipid complex formulation).
