The researchers identified high correspondence for plasma A?42/A?40 with amyloid
PET status (receiver operating characteristic area under the curve [AUC], 0.88) and CSF p-tau181/A?42 (AUC, 0.85).
"I think we've found a potential link between amyloid
and tau that people have been looking for for a long time," said senior author David Holtzman, MD, the Andrew B.
"This is the first study in which lipid molecules produced in the brain are found in the blood, as amyloid
deposition increases in Alzheimer's disease," said the lead author of the study, Dr.
Ultimately, investigators hope the US.-wide, open-label study will prove the clinical value of amyloid
PET scanning and convince the Centers for Medicare & Medicaid Services to make the test a fully covered service.
- New data provide compelling evidence to further support amyloid
hypothesis as a therapeutic target for Alzheimer's disease
The lab-grown cells from the Alzheimer's patients would have the same tendency to generate the excess amount of amyloid
beta and the Tau protein precursor that is seen in the brains cells of people with the disorder.
scans can tell us if someone is on the wrong path, but tau scans could tell us how fast they are going.
According to him, poor UPSIT sores are also related to brain levels of amyloid
beta and are almost as predictive of cognitive decline.
Noting that past research has found that the brain clears up deposits of amyloid
plaque during sleep, Hogan hypothesised that apnoea may impede this process.
The team hope that removing this amyloid
buildup at the very earliest signs could help to slow down or even prevent Alzheimer's disease.
It seems that tau protein is involved in several degenerative diseases, and beta amyloid
triggers pathological tau protein (26, 27).
Deepak Kumar and other scientists at Massachusetts General Hospital tested that idea in the lab by creating mice that were unable to produce amyloid