amyloid

(redirected from amyloid plaque)
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amyloid

[′am·ə‚lȯid]
(pathology)
An abnormal protein deposited in tissues, formed from the infiltration of an unknown substance, probably a carbohydrate.
References in periodicals archive ?
indicates moderate to frequent amyloid plaques are present; this amount
Nor was there any promising strategy to uncover earlier causal events that preceded and/or contributed to the elevation of A[beta] that then was deposited within the amyloid plaques.
Alzheimer's disease (AD) is a complex neurodegenerative disease characterized by abnormal protein deposits - amyloid plaques (containing the AB1-42 peptide) and neurofibrillary tangles (containing tau protein) - in the brain.
Adults taking hypertensive medications, even those with genetic risk, had levels of amyloid plaque equivalent to participants without hypertension or genetic risk.
Amyloid plaques, the pathological hallmark of Alzheimer's disease, are
Based in Philadelphia, PA, the company's lead program is a molecular imaging agent for amyloid plaque that could lead to earlier detection and better evaluation of drugs designed to prevent or reverse amyloid plaque build-up in the brain.
Study 302: "A clinical study of two doses of a selective p38 MAP kinase inhibitor, VX-745, to evaluate the effects of 12-Week oral twice-daily dosing on amyloid plaque load as assessed by Quantitative Dynamic 11C-PiB positive emission tomography (PET) amyloid scanning".
This initially results in cognitive impairment, memory impairment and, later, an increase of amyloid plaque.
This pattern is completely consistent with the topology of amyloid plaque distribution found at autopsy in the brains of AD patients, Dr.
and his colleagues have begun working with researchers in Temple's Moulder Center for Drug Discovery Research to create more potent inhibitors that can target 5-lipoxygenase in the brain and increase the ability to reduce amyloid plaque formation and the development of Alzheimer's.
Based in Philadelphia, PA, the company is a pioneer in the development of molecular imaging agents for Alzheimer's disease that could lead to earlier diagnosis and better evaluation of drugs designed to prevent or reverse amyloid plaque build-up in the brain.
A positive Amyvid scan indicates moderate to frequent amyloid plaques are present; this amount of amyloid plaque is present in patients with Alzheimer's Disease, but may also be present in patients with other types of neurologic conditions and in older people with normal cognition.