Due to the aforementioned alternative treatment options, the course of our patient challenges the role of GLOA as a diagnostic and therapeutic tool in analgetic
medicine especially for atypical TN (especially when no conservative analgetic
treatment pathway was performed before any invasive method at all).
activity of calcitonin in patients with painful osteolytic metastases of breast cancer.
To improve tolerability compared to isolated salicyclic acid, Felix Hoffmann synthesised acetylsalicylic acid (ASA) in 1897, today one of the mostly consumed analgetic
and anti-inflammatory drugs worldwide.
In a study by Jamieson and Duffield (1990) naloxon failed to block the analgetic
effects of kava.
In case of Harpagophytum extracts, it is widely accepted that harpagoside is the major active constituent being responsible for the analgetic
and antiphlogistic potential, since in vitro studies in human whole blood showed that the inhibition of the biosynthesis of cysteinyl-leukotrienes strongly depended on the harpagoside content, whereas extract fractions without harpagoside had no effects (Loew et al., 2001).