anaphase-promoting complex


Also found in: Medical, Wikipedia.

anaphase-promoting complex

[¦an·ə·fāz prə‚mōd·iŋ ′käm‚pleks]
(cell and molecular biology)
A large protein complex activated during mitosis that promotes the metaphase to anaphase transition by effecting the proteolytic destruction of several key mitotic regulators. Abbreviated APC.
Mentioned in ?
References in periodicals archive ?
The anaphase-promoting complex (APC/C) is a large multi-subunit complex (over 1.2 MDa in humans) composed of approximately 20 different subunits.
Kirschner, "Control of mitotic transitions by the anaphase-promoting complex," Philosophical Transactions of the Royal Society of London: Series B, Biological Sciences, vol.
[5] Nonstandard abbreviations: PIP3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PI3K, phosphatidylinositol 3-kinase; APC, anaphase-promoting complex.
A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first detailed images of the anaphase-promoting complex (APC/C).
Peters, "The anaphase-promoting complex: proteolysis in mitosis and beyond," Molecular Cell, vol.
Brand, "Independent regulation of synaptic size and activity by the anaphase-promoting complex," Cell, vol.