anaphase-promoting complex


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anaphase-promoting complex

[¦an·ə·fāz prə‚mōd·iŋ ′käm‚pleks]
(cell and molecular biology)
A large protein complex activated during mitosis that promotes the metaphase to anaphase transition by effecting the proteolytic destruction of several key mitotic regulators. Abbreviated APC.
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Objective: This research proposal describes an ambitious effort to characterize structurally and biochemically ubiquitin chain initiation and elongation by the anaphase-promoting complex or cyclosome (APC/C) in complex with two well-characterized substrates.
5] Nonstandard abbreviations: PIP3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PI3K, phosphatidylinositol 3-kinase; APC, anaphase-promoting complex.
A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first detailed images of the anaphase-promoting complex (APC/C).