anaphase-promoting complex

[¦an·ə·fāz prə‚mōd·iŋ ′käm‚pleks]

(cell and molecular biology)

A large protein complex activated during mitosis that promotes the metaphase to anaphase transition by effecting the proteolytic destruction of several key mitotic regulators. Abbreviated APC.

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References in periodicals archive ?

The anaphase-promoting complex (APC/C) is a large multi-subunit complex (over 1.2 MDa in humans) composed of approximately 20 different subunits.

Structure and mechanism of the anaphase promoting complex and its regulation by the spindle assembly checkpoint

Kirschner, "Control of mitotic transitions by the anaphase-promoting complex," Philosophical Transactions of the Royal Society of London: Series B, Biological Sciences, vol.

Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint

[5] Nonstandard abbreviations: PIP3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PI3K, phosphatidylinositol 3-kinase; APC, anaphase-promoting complex.

Regulation of the phosphatidylinositide 3-kinase pathway by the lipid phosphatase PTEN

A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first detailed images of the anaphase-promoting complex (APC/C).

New cell study might help fight cancer

Peters, "The anaphase-promoting complex: proteolysis in mitosis and beyond," Molecular Cell, vol.

A synthetic interaction between CDC20 and RAD4 in Saccharomyces cerevisiae upon UV irradiation

Brand, "Independent regulation of synaptic size and activity by the anaphase-promoting complex," Cell, vol.