anaphase-promoting complex

[¦an·ə·fāz prə‚mōd·iŋ ′käm‚pleks]

(cell and molecular biology)

A large protein complex activated during mitosis that promotes the metaphase to anaphase transition by effecting the proteolytic destruction of several key mitotic regulators. Abbreviated APC.

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References in periodicals archive ?

Objective: This research proposal describes an ambitious effort to characterize structurally and biochemically ubiquitin chain initiation and elongation by the anaphase-promoting complex or cyclosome (APC/C) in complex with two well-characterized substrates.

APCINTERACTIONS: Molecular basis for securin and cyclin ubiquitylation by the anaphase-promoting complex (APC/C)

5] Nonstandard abbreviations: PIP3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PI3K, phosphatidylinositol 3-kinase; APC, anaphase-promoting complex.

Regulation of the phosphatidylinositide 3-kinase pathway by the lipid phosphatase PTEN

A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first detailed images of the anaphase-promoting complex (APC/C).