anaphase-promoting complex

[¦an·ə·fāz prə‚mōd·iŋ ′käm‚pleks]

(cell and molecular biology)

A large protein complex activated during mitosis that promotes the metaphase to anaphase transition by effecting the proteolytic destruction of several key mitotic regulators. Abbreviated APC.

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References in periodicals archive ?

Kirschner, "Control of mitotic transitions by the anaphase-promoting complex," Philosophical Transactions of the Royal Society of London: Series B, Biological Sciences, vol.

Oxidative Stress Delays Prometaphase/Metaphase of the First Cleavage in Mouse Zygotes via the MAD2L1-Mediated Spindle Assembly Checkpoint

[5] Nonstandard abbreviations: PIP3, phosphatidylinositol 3,4,5-trisphosphate; PKB, protein kinase B; PI3K, phosphatidylinositol 3-kinase; APC, anaphase-promoting complex.

Regulation of the phosphatidylinositide 3-kinase pathway by the lipid phosphatase PTEN

A team from The Institute of Cancer Research, London, and the Medical Research Council Laboratory of Molecular Biology in Cambridge produced the first detailed images of the anaphase-promoting complex (APC/C).

New cell study might help fight cancer

Peters, "The anaphase-promoting complex: proteolysis in mitosis and beyond," Molecular Cell, vol.

A synthetic interaction between CDC20 and RAD4 in Saccharomyces cerevisiae upon UV irradiation

Brand, "Independent regulation of synaptic size and activity by the anaphase-promoting complex," Cell, vol.