Citrate: Rock Creek Pharmaceuticals' compound is a small molecule, cholinergic agonist that exhibits anti-inflammatory pharmacological characteristics, distinct from other anti-inflammatory drugs available such as biologics, steroids and non-steroidal anti-inflammatories.
is derived from tobacco, and it has been used as a biologic lab marker for determining tobacco use during smoking cessation trials.
Of interest are those that are shared with tobacco, such as anatabine
(an alkaloid with anti-inflammatory properties) and capsinoids (which stimulate receptors in the substatia nigra and thus may affect survival of mid-brain dopaminergic neurons).
This double-blind, randomized, placebo-controlled, parallel-group trial will evaluate the safety, tolerability and potential effects of Anatabine
dietary supplementation in subjects with mild to moderate Alzheimer's disease.
Gas chromatographic-mass spectrometric method for determination of anabasine, anatabine
and other tobacco alkaloids in urine of smokers and smokeless tobacco users.
and anabasine) in the tobacco plant to be decreased or increased through genetic engineering and plant breeding.
Effects of a facial cream containing the minor alkaloid anatabine
on improving the appearance of the skin in mild to moderate rosacea: an open-label case series study.
Anatabloc, developed by the company's Rock Creek Pharmaceuticals subsidiary, contains anatabine
Allowance for the Administration of Anatabine
to Treat Autism Spectrum and Seizure Disorders and Third Quarter Results
Citrate: Rock Creek Pharmaceuticals' compound is a small molecule, cholinergic agonist which exhibits anti-inflammatory pharmacological characteristics, distinct from other anti-inflammatory drugs available such as biologics, steroids and non-steroidal anti-inflammatories.
MPO expression can be either down-regulated or up-regulated to produce tobacco plant varieties and tobacco products with a wide range of nicotine levels (from very low to high), or altered ratios of nicotine and other nicotinic alkaloids such as anatabine
The overall objective of the Phase I trial was to evaluate safety, tolerability and pharmacokinetic (PK) profiles of different formulations of the Company's lead compound, Anatabine
Citrate, in healthy volunteers.