toxoid(redirected from anatoxin)
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(also anatoxin), a harmless derivative of a toxin that retains its antigenic and immunogenic properties. It is obtained by rendering the toxin harmless with formalin at 37–40°C. A toxoid suitable for immunizing human beings was first obtained in 1923 by the French immunologist G. Ramon. Tetanus and diphtheria toxoids are used as prophylactic measures against these infections. Staphylococcal, botulin, and dysentery toxoids, toxoids produced by the causative agents of gas gangrene and made from the poisons of some poisonous snakes, and other toxoids have been produced and are used for specific prophylaxis and treatment. Toxoids are also used for immunizing horses in order to obtain medicinal antitoxic serums (antitetanus and antidiphtheria).
T. I. BULATOVA