androgen


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androgen

(ăn`drəjən): see testosteronetestosterone
, principal androgen, or male sex hormone. One of the group of compounds known as anabolic steroids, testosterone is secreted by the testes (see testis) but is also synthesized in small quantities in the ovaries, cortices of the adrenal glands, and placenta, usually
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.

Androgen

One of a class of steroid hormones. Androgens play a major role in the development and maintenance of masculine secondary sexual characters, for example, the seminal vesicle and prostate gland of the male mammal, and the comb, wattles, and spur of the male fowl. They also influence certain other secondary sexual characters, such as hair growth pattern and voice quality in humans. In the fowl, they affect the pattern and seasonal coloration of its feathers, as well as crowing. In addition, androgens affect nitrogen metabolism (anabolic). Androgens are produced in the testis, ovary, adrenal, and most likely, in the placenta. A small portion of the androgen is from corticoids, or adrenal cortex steroids, and from other C21 steroids, such as progesterone. See Hormone, Ovary, Progesterone, Steroid, Testis

androgen

[′an·drə·jən]
(biochemistry)
A class of steroid hormones produced in the testis and adrenal cortex which act to regulate masculine secondary sexual characteristics.
References in periodicals archive ?
Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer.
Recruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.
Based on this study, which is really, I think a pivotal, definitive trial of this question, IAS [intermittent androgen suppression] should be the standard of care for most patients with PSA [prostate-specific antigen] recurrence after radiation, who are initiating androgen deprivation therapy," he said.
Thus, experimental data and clinical results concur in indicating a correlation between fusion gene expression and the role of the androgen pathway.
It appears that insulin resistance creates a vicious cycle that shifts into androgen excess and the androgen excess then promotes insulin resistance.
Concern about adverse effects of androgen deprivation therapy on bone is based on four retrospective studies and a case-control study showing an increase risk for both fragility fractures and nonfragility fractures with its use, according to Dr.
Androgens have been described as any chemical with testosterone-like action.
In the premenopausal woman, androgen production is approximately equally divided between the adrenal gland and the ovaries.
KEY WORDS: androgen-independent, androgen receptor, arsenic, cancer progression, hormone refractory, malignant transformation, MAP kinase, prostate, Ras.
Apalutamide is an investigational, next-generation oral androgen receptor inhibitor that inhibits the action of androgen in prostate cancer cells, and prevents binding of androgen to the androgen receptor, and translocation of the androgen receptor to the nucleus of the cancer cell.
This study found that the androgen receptor signaling could be disrupted using a novel class of drugs called peptidomimetics.
Androgen ablation therapy are generally known as the first line of treatment and thus expected to hold maximum revenue share in overall hormone sensitive prostate cancer treatment market.