androgen


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androgen

(ăn`drəjən): see testosteronetestosterone
, principal androgen, or male sex hormone. One of the group of compounds known as anabolic steroids, testosterone is secreted by the testes (see testis) but is also synthesized in small quantities in the ovaries, cortices of the adrenal glands, and placenta, usually
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.

Androgen

One of a class of steroid hormones. Androgens play a major role in the development and maintenance of masculine secondary sexual characters, for example, the seminal vesicle and prostate gland of the male mammal, and the comb, wattles, and spur of the male fowl. They also influence certain other secondary sexual characters, such as hair growth pattern and voice quality in humans. In the fowl, they affect the pattern and seasonal coloration of its feathers, as well as crowing. In addition, androgens affect nitrogen metabolism (anabolic). Androgens are produced in the testis, ovary, adrenal, and most likely, in the placenta. A small portion of the androgen is from corticoids, or adrenal cortex steroids, and from other C21 steroids, such as progesterone. See Hormone, Ovary, Progesterone, Steroid, Testis

androgen

[′an·drə·jən]
(biochemistry)
A class of steroid hormones produced in the testis and adrenal cortex which act to regulate masculine secondary sexual characteristics.
References in periodicals archive ?
The Androgens and Androgen Receptors have important roles both in the development of normal as well malignant prostate gland.15,28
Androgen receptor (AR) malfunction is associated with acne.5 Patients with androgen excess, like Cushing's syndrome, Polycystic Ovaries (PCOs) and CAH, can all have acne.
Through the immunohistochemistry method using Dako reagents, the presence of Androgen receptor in the above group of 72 patients were studied.
The study of androgen receptors in mammalian ovary and oviduct has been reported extensively (Shao et al., 2007; Horne et al., 2009; Okada et al., 2003).
They can be seen in the testicular interstitium, and the intensity was significantly decreased after androgen deprivation.
Although these studies showed that cryptotanshinone could reduce androgen synthesis, they did not establish the molecular mechanism behind this effect.
We all have androgens in our bodies, although men have 10 times more than women.
"We are hopeful that this novel class of drugs will shut down androgen receptor signaling and lead to added options and increased longevity for men with advanced prostate cancer," says urologist Ganesh Raj of the University of Texas Southwestern Medical Center, Dallas, senior author of the study.
Nead and colleagues evaluated medical records from the Stanford health system and New York's Mount Sinai Hospital for 16,888 nonmetastatic prostate cancer patients, of whom 2,397 received androgen deprivation therapy.
Sjogren's syndrome involves a change in the androgen-oestrogen ratio--without the anti-inflammatory effect of androgens in these androgen deficient patients, excessive amounts of inflammation occur.
The McMaster data presented at the 2014 meeting adds to this body of knowledge as it appears that at least part of the deleterious metabolic effects of androgen deprivation therapy (ADT) may lie in its FSH-suppressing activity and not all due to lowering of testosterone.