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Deposition of amyloid in one or more organs of the body.



or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.


References in periodicals archive ?
But task force members disagreed about the serum testosterone threshold that should trigger therapy in older men with symptoms of androgen deficiency, Dr.
Serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels are useful for distinguishing between primary and secondary androgen deficiency in patients with a confirmed diagnosis.
Effects of androgen deficiency and replacement on prostate zonal volumes.
Key indications for androgen replacement in postmenopausal women with clinical symptoms of androgen deficiency include adequate estrogen status and having free testosterone levels at or below the lowest quartile for reproductive age.
18] In a third trial, oral testosterone 120 mg/d plus sildenafil was associated with a small but significant increase in the erectile function domain and Partial Androgen Deficiency of Ageing Male (PADAM) scores compared with sildenafil and placebo in hypogonadal men with serum testosterone 210 ± 40 ng/dL (7.
As part of his study evaluating transdermal testosterone patch therapy in men with opioid-induced androgen deficiency, Dr.
Interest of the androgen deficiency in aging males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers.
Testosterone therapy in men with androgen deficiency syndromes: An Endocrine Society clinical practice guideline.
He then highlighted the findings from Meta-Analysis of thirty studies of Androgen deficiency in men wherein 100mg of Viagra was used.
They hope that someday clinical trials will test a novel regenerative medicine approach to treat androgen deficiency in men.
10,11,12) Androgen deficiency may lead to meibomian gland dysfunction and evaporative dry eye syndrome.
Transition Therapeutics advances novel therapeutics for CNS, metabolic diseases and androgen deficiency indications.

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