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The data in this study demonstrates that the commonest cause of XY DSD is androgen insensitivity syndrome, PAIS (45%) being much more common than CAIS (8.
This was also highlighted in one of the undervirilized 7 years, male patient with a very small phallus, developed vagina and complete androgen insensitivity syndrome.
Minto, 60 of 67 patients with complete androgen insensitivity syndrome (CAIS) were sexually active; among these women, there was an 88% rate of sexual dysfunction and a 42% rate of severe dysfunction.
A distinctive form of Type II intersexuality is called complete androgen insensitivity syndrome (AIS), or testicular feminization.
Weir examines the various theories as to the reasons for her revulsion, from feminine independence to fear of childbirth - even the suggestion that she was alike with the Duchess of Windsor in being the victim of a condition known as Androgen Insensitivity Syndrome, under which sufferers are born with male XY chromosomes but develop outwardly as females, albeit lacking the physical capacity for pregnancy.
Clinical evidence can be derived from patients who have the androgen insensitivity syndrome as a result of inactivating mutations in the androgen receptor gene.
Androgen insensitivity syndrome is extremely distressing to the concerned individuals and requires sympathetic handling.

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