Suppression

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Related to androgen suppression: Androgen Deprivation Therapy, androgen ablation

suppression

[sə′presh·ən]
(computer science)
Removal or deletion usually of insignificant digits in a number, especially zero suppression.
Optional function in either on-line or off-line printing devices that permits them to ignore certain characters or groups of characters which may be transmitted through them.
(electronics)
Elimination of any component of an emission, as a particular frequency or group of frequencies in an audio-frequency of a radio-frequency signal.

Suppression

 

in genetics, a phenomenon that prevents the appearance of a character resulting from mutation and that causes partial or complete restoration of the normal phenotype.

Intragenic suppression is caused by a second (suppressor) mutation in the same gene in which the first (direct) mutation occurred. Intergenic suppression is caused by a second mutation in other genes that are located at a considerable distance from the suppressed gene. In intragenic suppression, a protein coded by a given gene can reacquire functional activity, although its original structure, in contrast to true reverse mutation, or reversion, is not restored. In intergenic suppression, the normal phenotype may be restored in some cases owing to mutations that permit other means of metabolism which do not require the functioning of the given gene. In other cases, the normal phenotype may be restored as a result of mutations that alter the process by which the genetic information of the mutant gene is realized.

The phenomenon of suppression, first discovered in 1920 by the American geneticist A. H. Sturtevant, is used to study the genetic code and other aspects of molecular genetics.

REFERENCE

Stent, G. Molekuliarnaia genetika. Moscow, 1974. Chapter 6. (Translated from English.)

I. I. TOLSTORUKOV

References in periodicals archive ?
Significant adverse events were similar between the intermittent androgen suppression and continuous androgen deprivation patients, including erectile dysfunction (86% vs.
The researchers reported that the only significant side effects were related to the androgen suppression therapy.
A phase III protocol of androgen suppression (AS) and 3DCRT/IMRT versus AS and 3DCRT/IMRT followed by chemotherapy (CT) with docetaxel and prednisone for localized, high-risk prostate cancer (RTOG 0521).
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Androgen suppression and radiation vs radiation alone for prostate cancer: A randomized trial.
Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions.
Causes of death in men undergoing androgen suppression therapy for newly diagnosed localized or recurrent prostate cancer.
3] In addition to the overt manifestations of androgen suppression, fundamental aspects of endocrine balance are altered through increased fat mass, which contributes to chronic comorbidities and may facilitate tumour progression.
The concept of similar efficacy between the two methods of androgen suppression has been challenged on the basis that an escape phenomenon occurs in some men treated with gonadotropin agonists and this results in an elevation of serum testosterone above castrate levels, potentially leading to unsatisfactory tumor control.
External irradiation with or without long term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study.
However, variations in the duration of androgen suppression were not correlated to testosterone levels and were controlled for in the multivariable analysis.

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