Suppression

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Related to androgen suppression: Androgen Deprivation Therapy, androgen ablation

suppression

[sə′presh·ən]
(computer science)
Removal or deletion usually of insignificant digits in a number, especially zero suppression.
Optional function in either on-line or off-line printing devices that permits them to ignore certain characters or groups of characters which may be transmitted through them.
(electronics)
Elimination of any component of an emission, as a particular frequency or group of frequencies in an audio-frequency of a radio-frequency signal.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Suppression

 

in genetics, a phenomenon that prevents the appearance of a character resulting from mutation and that causes partial or complete restoration of the normal phenotype.

Intragenic suppression is caused by a second (suppressor) mutation in the same gene in which the first (direct) mutation occurred. Intergenic suppression is caused by a second mutation in other genes that are located at a considerable distance from the suppressed gene. In intragenic suppression, a protein coded by a given gene can reacquire functional activity, although its original structure, in contrast to true reverse mutation, or reversion, is not restored. In intergenic suppression, the normal phenotype may be restored in some cases owing to mutations that permit other means of metabolism which do not require the functioning of the given gene. In other cases, the normal phenotype may be restored as a result of mutations that alter the process by which the genetic information of the mutant gene is realized.

The phenomenon of suppression, first discovered in 1920 by the American geneticist A. H. Sturtevant, is used to study the genetic code and other aspects of molecular genetics.

REFERENCE

Stent, G. Molekuliarnaia genetika. Moscow, 1974. Chapter 6. (Translated from English.)

I. I. TOLSTORUKOV

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Significant adverse events were similar between the intermittent androgen suppression and continuous androgen deprivation patients, including erectile dysfunction (86% vs.
A phase III protocol of androgen suppression (AS) and 3DCRT/IMRT versus AS and 3DCRT/IMRT followed by chemotherapy (CT) with docetaxel and prednisone for localized, high-risk prostate cancer (RTOG 0521).
The Androgen Suppression Combined With Elective Nodal and Dose Escalated Radiation Therapy (ASCENDE-RT) study included 122 patients with intermediate- and high-risk PCa.
While there is agreement about the need for androgen suppression in hormone-sensitive prostate cancer, optimal testoster-one levels on ADT remains a matter of debate.
A consensus by the American College of Sports Medicine (ACSM)[sup.21] on exercise and cancer determined that exercise is a safe and effective means of reducing many of the side effects associated with prostate cancer treatment and androgen suppression. In general, the ACSM recommends moderate-intensity aerobic physical activity for a minimum of 30 minutes, 5 days per week, or vigorous-intensity aerobic activity for a minimum of 20 minutes, 3 days per week, to promote and maintain health in older adults.[sup.22] Resistance training should be performed a minimum of 2 days a week, incorporating 8 to 10 exercises with 10 to 15 repetitions using major muscle groups during each session.
Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions.
Causes of death in men undergoing androgen suppression therapy for newly diagnosed localized or recurrent prostate cancer.
Androgen deprivation therapy (ADT) is indicated for locally advanced and metastatic prostate cancer to slow disease progression; it may be prescribed for several years.[sup.1] Unfortunately, ADT has significant side effects that compromise physical and psychological well-being, including increased fat mass, and reduced muscle mass and bone density, as well as worsened fatigue and quality of life.[sup.1]-[sup.3] In addition to the overt manifestations of androgen suppression, fundamental aspects of endocrine balance are altered through increased fat mass, which contributes to chronic comorbidities and may facilitate tumour progression.

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