androstane


Also found in: Dictionary, Thesaurus, Medical.

androstane

[′an·drə‚stān]
(biochemistry)
C19H32 The parent steroid hydrocarbon for all androgen hormones. Also known as etioallocholane.
Mentioned in ?
References in periodicals archive ?
Messenger RNA expression levels of pregnane X receptor, constitutive androstane receptor, and glucocorticoid receptor in the liver
The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepaticgene expression linked to thyroid hormone metabolism.
The neuroexcitatory androstane neurosteroids are testosterone-derived androgens.
Homology modelling of the nuclear receptors: Human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure.
Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.
In a collaboration with the UC San Diego SRC, Hammock and his team found that TCC treatment of mice activated both the constitutive androstane receptor and ER[alpha], leading to downstream induction of target genes (Yueh et al.
Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.
Importantly, in a feedforward manner, parent xenobiotic chemicals may also activate xenosensors such as AhR (aryl hydrocarbon receptor), CAR (constitutive androstane receptor), and PXR (pregnane X receptor), which directly induce phase II enzymes to detoxify reactive metabolites formed by phase I oxidative reactions.
Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.
Interestingly, TPP has been shown to interact with a variety of nuclear receptors, activating constitutive androstane receptor, pregnane X receptor, and estrogen receptor-mediated reporter activity and antagonizing androgen, progesterone, and glucocorticoid receptor-mediated reporter activity (Honkakoski et al.
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Hepatic CYP2136 expression: gender and ethnic differences and relationship to CYP2136 genotype and CAR (constitutive androstane receptor) expression.