androstane


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androstane

[′an·drə‚stān]
(biochemistry)
C19H32 The parent steroid hydrocarbon for all androgen hormones. Also known as etioallocholane.
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References in periodicals archive ?
Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR1 define three pharmacologically distinct classes of nuclear receptors.
Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database
The cytochromes chosen were biomarkers for activation of aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and PXR.
Global gene expression analysis in the livers of rat offspring perinatally exposed to low doses of 2,2',4,4'-tetrabromodiphenyl ether
Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
A reexamination of the PPAR-[alpha] activation mode of action as a basis for assessing human cancer risks of environmental contaminants
CYP3A also normally metabolizes food-derived activators of pregnane X receptor and/ or constitutive androstane receptor, thereby regulating the expression of a range of detoxifying systems in the liver (van Waterschoot et al.
Molecular population genetics of human CYP3A locus: signatures of positive selection and implications for evolutionary environmental medicine
Further study is required to understand the structure-activity relationship between PBDEs and their metabolites and nuclear hormone receptors, and their pleiotropic effects against other nuclear receptors such as PXR and constitutive androstane receptor.
Nuclear hormone receptor activity of polybrominated diphenyl ethers and their hydroxylated and methoxylated metabolites in transactivation assays using Chinese hamster ovary cells
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.
Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men
Coupled with the down-regulation of PXR, methapyrilene also induced a liver-dependent down-regulation of the constitutive androstane receptor (CAR/Nr1i3; GenBank accession no.
Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue
We therefore studied expression of the aryl hydrocarbon receptor (AHR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), liver X receptor (LXR), and glucocorticoid receptor (GR) (Gibson et al.
Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers

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