androstane

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androstane

[′an·drə‚stān]

(biochemistry)

C₁₉H₃₂ The parent steroid hydrocarbon for all androgen hormones. Also known as etioallocholane.

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etioallocholane

References in periodicals archive ?

Messenger RNA expression levels of pregnane X receptor, constitutive androstane receptor, and glucocorticoid receptor in the liver

Hepatic Cyp1a2 Expression Reduction during Inflammation Elicited in a Rat Model of Intermittent Hypoxia

The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepaticgene expression linked to thyroid hormone metabolism.

Identification of the Pig Constitutive Androstane Receptor (pgCAR) Agonist using a High-throughput Screening Assay

The neuroexcitatory androstane neurosteroids are testosterone-derived androgens.

Innovative integrative addiction treatment = unparalleled growth opportunity

Homology modelling of the nuclear receptors: Human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure.

International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression

In a collaboration with the UC San Diego SRC, Hammock and his team found that TCC treatment of mice activated both the constitutive androstane receptor and ER[alpha], leading to downstream induction of target genes (Yueh et al.

The NIEHS Superfund Research Program: 25 years of translational research for public health

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression.

MALDI-TOF mass spectrometry for multiplex genotyping of CYP2B6 single-nucleotide polymorphisms

Importantly, in a feedforward manner, parent xenobiotic chemicals may also activate xenosensors such as AhR (aryl hydrocarbon receptor), CAR (constitutive androstane receptor), and PXR (pregnane X receptor), which directly induce phase II enzymes to detoxify reactive metabolites formed by phase I oxidative reactions.

Molecular signaling network motifs provide a mechanistic basis for cellular threshold responses

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site.

CYP2C9*2 and CYP2C9*3 alleles confer a lower risk for myocardial infarction

Interestingly, TPP has been shown to interact with a variety of nuclear receptors, activating constitutive androstane receptor, pregnane X receptor, and estrogen receptor-mediated reporter activity and antagonizing androgen, progesterone, and glucocorticoid receptor-mediated reporter activity (Honkakoski et al.

Ligand binding and activation of PPAR[gamma] by Firemaster[R] 550: effects on adipogenesis and osteogenesis in vitro

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.

Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals

Hepatic CYP2136 expression: gender and ethnic differences and relationship to CYP2136 genotype and CAR (constitutive androstane receptor) expression.

Identification of CYP2B6 Sequence variants by use of multiplex PCR with allele-specific genotyping