androstane

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androstane

[′an·drə‚stān]

(biochemistry)

C₁₉H₃₂ The parent steroid hydrocarbon for all androgen hormones. Also known as etioallocholane.

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etioallocholane

References in periodicals archive ?

Role of constitutive androstane receptor in Toll-like receptor-mediated regulation of gene expression of hepatic drug-metabolizing enzymes and transporters.

Hepatic Cyp1a2 Expression Reduction during Inflammation Elicited in a Rat Model of Intermittent Hypoxia

Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

Identification of the Pig Constitutive Androstane Receptor (pgCAR) Agonist using a High-throughput Screening Assay

Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.

Expression of NR1I3 in mouse lung tumors induced by the tobacco-specific nitrosamine 4-(methylnitrosamino)-4-(3-pyridyl)-1-butanone

(197) Specifically, the court found that, although five of eighteen disclosed androstanes were claimed, the specification did not identify which androstanes were useful or what biological properties they possessed:

In re Dane K. Fisher: an exercise in utility

Role of Constitutive Androstane Receptor in Pesticide-Induced Metabolic Perturbations

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

Yamazoe, "Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region," Biochemical Pharmacology, vol.

Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

Homology modelling of the nuclear receptors: Human oestrogen receptorbeta (hERbeta), the human pregnane-X-receptor (PXR), the Ah receptor (AhR) and the constitutive androstane receptor (CAR) ligand binding domains from the human oestrogen receptor alpha (hERalpha) crystal structure, and the human peroxisome proliferator activated receptor alpha (PPARalpha) ligand binding domain from the human PPARgamma crystal structure.

International regulatory needs for development of an IATA for non-genotoxic carcinogenic chemical substances

Negishi et al., "Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity," Journal of Biological Chemistry, vol.

Coordinated actions of FXR and LXR in metabolism: from pathogenesis to pharmacological targets for type 2 diabetes

Induction of CYP3A4, CYP2C19, and CYP2C9 by the prenyloxycinnamic acids is most likely mediated via the pregnane x receptor (PXR), which regulates the expression of many CYPs and which is the major nuclear receptor in LS180 cells lacking the constitutive androstane receptor (CAR) (Gupta et al.

In vitro effects of natural prenyloxycinnamic acids on human cytochrome P450 isozyme activity and expression

There are two groups of families of neurosteroids: the inhibitory neurotransmitter receptor families of pregnane neurosteroids that include allopregnanolone and aIlotetrahydrodeoxycorticosterone, and the excitatory neurotransmitter receptor families of androstane neurosteroids, such as androstanediol and etiocholanone.

Innovative integrative addiction treatment = unparalleled growth opportunity

Some PBDEs have been shown to cause pregnane X receptor (PXR)--and constitutive androstane receptor (CAR)-mediated induction of liver enzymes responsible for thyroid hormone clearance, which might compromise brain development by causing thyroid hormone insufficiency (EFSA 2011; Costa and Giordano 2011).

A human mixture risk assessment for neurodevelopmental toxicity associated with polybrominated diphenyl ethers used as flame retardants

Augustine et al., "The Nrf2 activator oltipraz also activates the constitutive androstane receptor," Drug Metabolism and Disposition, vol.

Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3K/Akt/Nrf2 Pathway