androstane


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androstane

[′an·drə‚stān]
(biochemistry)
C19H32 The parent steroid hydrocarbon for all androgen hormones. Also known as etioallocholane.
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Intestinal human colon adenocarcinoma cell line LS180 is an excellent model to study pregnane X receptor, but not constitutive androstane receptor, mediated CYP3A4 and multidrug resistance transporter 1 induction: studies with anti-human immunodeficiency virus protease inhibitors.
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR1 define three pharmacologically distinct classes of nuclear receptors.
The cytochromes chosen were biomarkers for activation of aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), and PXR.
Induction of nuclear translocation of constitutive androstane receptor by peroxisome proliferator-activated receptor alpha synthetic ligands in mouse liver.
CYP3A also normally metabolizes food-derived activators of pregnane X receptor and/ or constitutive androstane receptor, thereby regulating the expression of a range of detoxifying systems in the liver (van Waterschoot et al.
Further study is required to understand the structure-activity relationship between PBDEs and their metabolites and nuclear hormone receptors, and their pleiotropic effects against other nuclear receptors such as PXR and constitutive androstane receptor.
Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism.
Coupled with the down-regulation of PXR, methapyrilene also induced a liver-dependent down-regulation of the constitutive androstane receptor (CAR/Nr1i3; GenBank accession no.
We therefore studied expression of the aryl hydrocarbon receptor (AHR), constitutive androstane receptor (CAR), pregnane X receptor (PXR), liver X receptor (LXR), and glucocorticoid receptor (GR) (Gibson et al.