Persons who do not mount a DTH response are considered to be anergic
and to be at elevated risk for complications of deficient cell-mediated immunity.
Immunologically, Lucio's phenomenon occurs in patients considered the most anergic
of the all-immunological spectrum of leprosy.
cutaneous leishmaniasis versus lobomycosis, Int J Dermatol 1996;35:438-40.
But 25 patients had negative responses to all allergens, and 3 patients were anergic
Seven (41%) of the residents had positive tuberculin reactions ([is greater than or equal to] 5 mm); one (6%)had a negative tuberculin reaction (0 mm) with positive reactions to companion delayed-type hypersensitivity (DTH) skin-test antigens (mumps and Candida); and nine (53%) were anergic
. Four (29%) of the staff had positive tuberculin reactions ([is greater than or equal to] 5 mm); one had previously had a negative tuberculin reaction.
Das et al., "Enhanced lesional Foxp3 expression and peripheral anergic
lymphocytes indicate a role for regulatory T cells in Indian postkala-azar dermal leishmaniasis," The Journal of Investigative Dermatology, vol.
Whether the patient was anergic
to SARS-CoV infection is unknown.
MAOIs have shown particular efficacy in certain subtypes of depression, including atypical depression, anergic
depression, and bipolar depression.
HIV-seropositive persons who are known contacts of patients with infectious TB should be considered for preventive therapy once active TB has been ruled out.
The PE-NK cells are not anergic
or exhausted as they respond well to IL-2 in vitro , and even healthy donor NK cells are strongly conditioned by the PE.
PPD responses are less useful in the renal failure population, who tend to be anergic
. Two of our patients did have PPD tests during diagnostic workup; results were negative.
Toda et al., "Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic
and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state," International Immunology, vol.