anergy

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anergy

[′a‚nər·jē]
(immunology)
The condition of exhibiting no response to an antigen or antibody.
(medicine)
The condition of exhibiting a lack of energy.
References in periodicals archive ?
All TST-negative adult subjects prior to ART were anergic, a reflection of poor immunity rather than identification of a group without prior TB infection.
4%) of the 41 immunosuppressed patients were anergic compared with 57 (73.
The advantages of tumor cell-based cancer vaccines must be balanced against two major disadvantages: the potential for autoimmunity and the potential for increasing the anergic status of the T cells due to the lack of functional co stimulatory molecules on tumor cells.
Criteria for enrollment included having a positive or anergic tuberculin skin test response, living within 20 kilometers of the project site, and willingness to be followed.
Cell extrinsic elements include factors contributing towards immune tolerance; some incriminated in the multistep carcinogenesis of HPV induced cervical cancer are: immunoregulatory enzyme indoleamine 2,3-dioxygenase expressing antigen presenting cells, low numbers of invariant Natural Killer T cells, anergic cytotoxic T lymphocytes, regulatory T cells (Tregs), an immunoregulatory microenvironment comprising of increased ILl0, TGF and reduced IL2; reduced intralesional ratios of effectors (CD4 and CD8) vs.
Recent studies suggest the ELISA serological tests are often negative for scrub typhus for up to 30 days following symptoms, as patients may be anergic and not produce antibodies during the early stages of scrub typhus.
Naturally anergic and suppressive CD4+CD25+ T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation.
It is an anergic variant of localized CL in which lesions are disseminated, resembling lepromatous leprosy.
During my medical residency nearly 30 years ago, while my team was discussing an elderly anergic patient, I mentioned a study I had seen indicating that topical application of zinc can reverse anergy.
This includes very early onset or leaden, anergic episodes more characteristic of bipolar depression.
19) Immune patients naturally showed the strongest reaction, although anergic or previously nonresponsive patients with disseminated coccidioidomycosis also showed increases in lymphocytes after exposure to the dendritic cells.