Studies have also shown that men with higher frequencies of
aneuploid sperm may be at a higher risk of fathering an
aneuploid child (Lowe et al.
Cytology, evolution and origin of the
aneuploid series in the genus Carex.
Chromosome data in amphibians and plants were collected at late larvae or young plant stages and are therefore biased because of the likely differential mortality of
aneuploids (Myers, 1944; Punyasingh, 1947; Fankhauser and Humphrey, 1950, 1954).
They also showed that with increased sequence tags there was increased precision of calling a sample
aneuploid (22).
Ms Lesser: Have you seen that patients who repeatedly produce
aneuploid embryos are better able to move on to donor eggs or adoption once they acquire this information?
"Even though cancer can arise from a set of precise mutations, the majority of malignant tumors possess
aneuploid cells, and the reason for this is still an open question," said Di Carlo, who is also a member of the California NanoSystems Institute at UCLA.
It is possible that flies obtained in this manner will also have rare XO flies (that is,
aneuploid flies with only one X chromosome) that survive the heat shock since they lack the Y{hs-hid} chromosome (see below).
Chromosomal abnormality at conception and birth have been reported to be 38 and 0.6 per cent, respectively (2) indicating natural selection against
aneuploid embryos from very early stage of pregnancy (3).
The
aneuploid series peaks in frequency at 28 and 30, with a second major peak at 35.
"A case in point is that carcinogen-induced mammary tumors in rodents are diploid, and human ductal breast cancers are seventy to ninety percent
aneuploid," says Li.
(1998) found that the restriction fragment length polymorphism locus XksuA1, mapped to 7DL through
aneuploid analysis, is linked to Dn2 at a distance of 9.8 centimorgans (cM).
However, other triploid bivalves, like the Japanese oyster (Crassostrea gigas) and the pearl oyster (Pinctada fucata), showed a limited number of
aneuploid gametes (Allen & Downing 1990, Komaru & Wada 1994).
