Global Hereditary Angioedema
Market, by Route of Administration
This Market Spotlight report covers the Hereditary Angioedema
market, comprising key pipeline and marketed drugs, clinical trials, upcoming and regulatory events, patent information, a 10-year disease prevalence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts
KalVista has developed a proprietary portfolio of novel, small molecule plasma kallikrein inhibitors initially targeting hereditary angioedema
and diabetic macular edema.
Dental-oral procedures, endoscopies or operations in general anesthesia can precipitate angioedema
. Plasma-derived C1-INH is recommended as short-term prophylactic treatment before triggering procedures.
The parents did not report any novel stressors or infection symptoms prior to the onset of angioedema
. He did not take any food supplements or medication except for fluoxetine.
They were aged between 7 and 70 years (mean: 34.5 y; median: 32 y), and 36/51 (70.6%) had a family history of suspected or confirmed hereditary angioedema
. Symptoms were reported in 46/51 (90.2%), and 5/51 (9.8%) remained asymptomatic.
The efficacy of the highest doses "was probably masked by gastrointestinal adverse events that may have been misattributed as early symptoms of abdominal angioedema
attacks," the investigators wrote in their analysis.
In the Phase III HELP (Hereditary Angioedema
Long-term Prophylaxis) Study supporting the US FDA's approval, the product decreased the number of monthly hereditary angioedema
attacks an average of 87% (n=27) vs placebo (n=41) when administered at 300mg every two weeks and 73% (n=29) vs placebo (n=41) when administered at 300mg every four weeks (Adjusted P
The researchers found that patients who received BCX7353 at daily doses of 125 mg or more had a significantly lower rate of confirmed angioedema
attacks compared with those who received placebo, with a 73.8 percent difference at 125 mg.
Bradykinin is a powerful vasodilator peptide that activates vascular bradykinin B2 receptors which are responsible for causing angioedema
. Bradykinin B2 receptors are upregulated in dying neurons such as that seen in ischemic CVA .