Inhibitor

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Related to angiogenesis inhibitor: tumor angiogenesis

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
References in periodicals archive ?
Angiogenesis inhibitors often cause tumor vessels to regress resulting in vessel normalization.
Papai et al., "Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancersoft tissue and bone sarcoma group (EORTC Study 62043)," Journal of Clinical Oncology, vol.
But new research suggests certain angiogenesis inhibitors may actually promote the growth of tumours.
Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).
Uzuki et al., "Treatment with the angiogenesis inhibitor endostatin: A novel therapy in rheumatoid arthritis," Journal of Rheumatology, vol.
Hirata, "Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin," Japanese Journal of Cancer Research, vol.
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.
The two bevacizumab arms also had similar progression-free survival: 4.8 months when the angiogenesis inhibitor was combined with chemotherapy and 4.4 months when it was used with erlotinib.
He is now being treated with an angiogenesis inhibitor in the hope that the tumor will not recur.
PTK/ZK is a novel, once daily oral angiogenesis inhibitor designed to target the tumor blood vessels slowing tumor growth and spread.
(NASDAQ: REGN), Tarrytown, N.Y., has initiated a Phase I clinical trial that is designed to assess the safety and tolerability of the company's VEGF Trap, a potent angiogenesis inhibitor, in patients with solid tumor malignancies and patients with non-Hodgkin's lymphoma.