often cause tumor vessels to regress resulting in vessel normalization.
McDonald, "Controlling escape from angiogenesis inhibitors
," Nature Reviews Cancer, vol.
Papai et al., "Pazopanib, a multikinase angiogenesis inhibitor
, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancersoft tissue and bone sarcoma group (EORTC Study 62043)," Journal of Clinical Oncology, vol.
But new research suggests certain angiogenesis inhibitors
may actually promote the growth of tumours.
Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor
Uzuki et al., "Treatment with the angiogenesis inhibitor
endostatin: A novel therapy in rheumatoid arthritis," Journal of Rheumatology, vol.
Hirata, "Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor
TNP-470 in combination with cisplatin," Japanese Journal of Cancer Research, vol.
Efficacy and toxicity of the angiogenesis inhibitor
SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.
The two bevacizumab arms also had similar progression-free survival: 4.8 months when the angiogenesis inhibitor
was combined with chemotherapy and 4.4 months when it was used with erlotinib.
He is now being treated with an angiogenesis inhibitor
in the hope that the tumor will not recur.
PTK/ZK is a novel, once daily oral angiogenesis inhibitor
designed to target the tumor blood vessels slowing tumor growth and spread.
(NASDAQ: REGN), Tarrytown, N.Y., has initiated a Phase I clinical trial that is designed to assess the safety and tolerability of the company's VEGF Trap, a potent angiogenesis inhibitor
, in patients with solid tumor malignancies and patients with non-Hodgkin's lymphoma.