DISCUSSION: Angioid streaks are irregular, radiating, jagged, tapering lines that extend from the peripapillary area into the peripheral fundus that may occur in isolation or as the ocular manifestation of a systemic disease .
Recently, intravitreally administrated bevacizumab, a vascular endothelial growth factor (VEGF) inhibitor that is a full size antibody to all isoforms of VEGF-A, has been successfully used as an off label treatment on CNV secondary to angioid streaks [1,17].
Altman, "Angioid streaks
," Survey of Ophthalmology, vol.
of the fundus are the most common ocular findings and are associated with pseudoxanthoma elasticum 85% of the time.
The pathology of angioid streaks
: a study of twenty-one cases.
Fundoscopic examination revealed angioid streaks
around the optic discs and peau d'orange appearance in the temporal macula of both eyes.
Mitral valve prolapse and aortic regurgitation have a higher prevalence in PXE than the general population.8 Characteristic ocular defect is angioid streaks
of retina, reddish-brown curvilinear bands that radiate from the optic disk.
are full thickness breaks in calcified and thickened Bruch's membrane.
Ayrica LCAT eksikliginde fundusta angioid streaks
benzeri bruch membran rupturu saptanan olgular bildirilmistir.
is a hereditary condition resulting in a degeneration of Bruch's membrane and the RPE.
Rare associations include retinitis pigmentosa (RP) and angioid streaks