GnRH receptors in the anterior pituitary
gonadotrophs are the primary regulation nodes for the secretion of FSH and LH.
Melmed, "Anterior pituitary
tumor syndromes," in Harrison's Principles of Internal Medicine, McGraw-Hill, New York, NY, USA, 2014.
For prolactin and TLR4 gene expression analyses, average relative quantity of gene expression in the control group of the anterior pituitary
explants collected from saline-treated ewes was set to 1.0.
As a result from clinical and hormonal phenotype highly variable [4-6], general properties of PROP1 mutation are a clinical disorder where GH deficiency is observed together with one or more anterior pituitary
It also appears that changes in plasma NEFA, as well as in glucose, might be involved in changing GH concentrations, because it has been reported that fatty acids directly inhibit GH secretion from cultured anterior pituitary
At the anterior pituitary
, CRF binds to CRF1 receptors and stimulates specific cells (i.e., corticotropic cells) to synthesize and secrete a peptide called proopiomelanocortin (POMC).
In this study, we examine an exploratory set of pituitary adenomas using IHC stains for Pit-1, SF-1, [alpha] subunit, CAM5.2, and standard anterior pituitary
NAC Decreases Nrf2 and HO-1 Expression in the Anterior Pituitary
of Wistar Rats.
In turn, GnRH regulates the secretion of luteinising hormone (LH) and follicle-stimulating hormone (FSH) from the gonadotropic cells in the anterior pituitary
gland (AP) .
The hypothalamus has an endocrine role via a cascade (e.g., during a stress response it secretes corticotrophic-releasing hormones, stimulating the anterior pituitary
gland to release some of its hormones, including ACTH, onto target organs like the adrenal cortex, and cells to release a family of hormones).
Basic endocrinology tests revealed the presence of anterior pituitary
dysfunction, associated with central diabetes insipidus and increased levels of inflammatory markers.
Low levels of thyroid hormones stimulate synthesis of TSH from anterior pituitary
, which in turn cause increased secretion of TRH from hypothalamus.