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McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.


Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Emergence of anthelmintic resistance in an organized sheep farm in Punjab.
Anthelmintic Resistance in Haemonchus contortus: History, Mechanisms and Diagnosis.
Rings, "Anthelmintic resistance of gastrointestinal parasites in small ruminants," Journal of Veterinary Internal Medicine, vol.
An inconvenient truth: Global warming and anthelmintic resistance. Veterinary Parasitology 186, 70-78.
The resistance of the drugs was tested according to the World Association for the Advancement of Veterinary Parasitology (WAAVP) recommendations for the detection of anthelmintic resistance in horses and ruminants [22] by the percentage reduction of mean egg excretion on the 14-day posttreatment; FECR% = 100(1 - [X.sub.t]/[X.sub.c]), where [X.sub.t] and [X.sub.c] are arithmetic means of EPG in the treated (t) and control (c) groups at day 14 posttreatment.
Anthelmintic resistance in cattle nematode in the western Pampeana Region of Argentina.
Ivermectin and febendazole anthelmintic resistance in gastrointestinal nematodes from naturally infected sheep in northern Tlaxcala, Mexico.
Recently Dever and Kahn [48] have demonstrated that anthelmintics extremely lipophilic as Mox administered at the rate of 1mg [kg.sup.-1] of body weight to lactating ewes could reduce significantly FEC in suckling offspring and expose lambs to subtherapeutic doses of the drug, a risk factor for the development of anthelmintic resistance. Our study employed only 200 mg [mL.sup.-1] and due to differences in treatment period application (late pregnancy or immediate peripartum), Tx offspring received lower Mox by milk than [T.sub.2].
Anthelmintics are essential for worm control and, to avoid anthelmintic resistance developing through frequent use and mis-use, a strategy must be developed.
Topics include descriptions of nematode parasites and their biology and life cycle, principles of control, anthelmintics and anthelmintic resistance, worm control and resistance management, non-chemical treatment options, nutrition and parasitism, and the immune response to parasites.