(redirected from anti-CCP)
Also found in: Dictionary, Thesaurus, Medical, Acronyms.


antibody, protein produced by the immune system (see immunity) in response to the presence in the body of antigens: foreign proteins or polysaccharides such as bacteria, bacterial toxins, viruses, or other cells or proteins. Such antigens are capable of inflicting damage by chemically combining with natural substances in the body and disrupting the body's processes. The body contains hundreds of thousands of different white blood cells called B lymphocytes, each capable of producing one type of antibody and each bearing sites on its membrane that will bind with a specific antigen. When such a binding occurs, it triggers the B lymphocyte to reproduce itself, forming a clone that manufactures vast amounts of its antibody.

The antibody molecule is composed of four polypeptide chains (see peptide)—two identical light chains and two identical heavy chains—joined by disulfide bridges. The light chains have a variable portion that is different in each type of antibody and is the active portion of the molecule that binds with the specific antigen. Antibodies combine with some antigens, such as bacterial toxins, and neutralize their effect; they remove other substances from circulation in body fluids; they bind certain antigens together, a process known as agglutination; and they activate complement, blood serum proteins that cause the destruction of invading cells.

See also monoclonal antibody.

The Columbia Electronic Encyclopedia™ Copyright © 2022, Columbia University Press. Licensed from Columbia University Press. All rights reserved.


A protein found principally in blood serum and characterized by a specific reactivity with the corresponding antigen. Antibodies are important in resistance against disease, in allergy, and in blood transfusions, and can be utilized in laboratory tests for the detection of antigens or the estimation of immune status.

Antibodies are normally absent at birth unless derived passively from the mother through the placenta or colostrum. In time, certain antibodies appear in response to environmental antigens. Antibodies are also induced by artificial immunization with vaccines or following natural infections. The resulting antibody level declines over a period of months, but rapidly increases following renewed contact with specific antigen, even after a lapse of years. This is known as an anamnestic or booster response. See Allergy, Blood groups, Hypersensitivity, Isoantigen, Vaccination

Antibody reactivity results in precipitation of soluble antigens, agglutination of particulate antigens, increased phagocytosis of bacteria, neutralization of toxins, and dissolution of bacterial or other cells specifically sensitive to their action; the antibodies so revealed are termed precipitins, agglutinins, opsonins, antitoxins, and lysins. One antibody may give many such reactions, depending on conditions, so these classifications are not unique or exclusive.

Three principal groups (IgG, IgM, IgA) and two minor groups (IgD, IgE) of antibodies are recognized. These all form part of the wider classification of immunoglobulins. Antibody diversity is generated by amino acid substitutions that result in unique antigen-binding structures. See Cellular Immunology, Immunoglobulin

The development of the technology for producing monoclonal antibodies, which can bind to specific sites on target antigens, revolutionized the uses of antibodies in biology and medicine. Unfortunately, almost all monoclonal antibodies originate in mice, and the murine immunoglobulin serves as an antigen, frequently acting immunogenic in human recipients. See Antigen, Monoclonal antibodies

McGraw-Hill Concise Encyclopedia of Bioscience. © 2002 by The McGraw-Hill Companies, Inc.


A protein, found principally in blood serum, originating either normally or in response to an antigen and characterized by a specific reactivity with its complementary antigen. Also known as immune body.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


any of various proteins produced in the blood in response to the presence of an antigen. By becoming attached to antigens on infectious organisms antibodies can render them harmless or cause them to be destroyed
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
The anti-CCP IgG levels from the same subjects were also quantified with an ADVIA Centaur XPT immunoassay system and the ADVIA Centaur anti-CCP assay kit.
Patients characteristics Characteristics n (%) (Patients) n (%) (Controls) Median age 51 (20-76) 49 (27-79) (years old) Gender Men 14 (13.3) 14 (12.7) Women 91 (86.7) 96 (87.3) ARA functional classification Stage 1 100 (95.2) Stage 2 4 (3.8) Stage 3 1 (1) Morning stiffness No 41 (39.1) 0-30 minutes 44 (41.9) >30 minutes 20 (19) RF Negative 55 (52.4) Positive 50 (47.6) ANA 1 positive 4 (3.8) 2 positive 14 (13.3) 3 positive 4 (3.8) 4 positive 4 (3.8) Negative 79 (75.2) Anti-CCP Negative 22 (20.9) Positive 42 (40) CRP Median 6,0 (2,0-62,0) RF: Rheumatoid factor; Anti-CCP: Anti-cyclic citrullinated peptide; ANA: Anti nuclear antibody Table 2.
These citrullinated proteins are believed to trigger an immune response by binding to HLA-DRB1 SE molecules on antigen presenting cells, leading to activation of pathogenic T and B cells, and ultimately promoting anti-CCP antibodies formation.1
(2) In a setting of relatively high clinical suspicion (high pretest probability), a positive anti-CCP result means the patient has a strong likelihood of having or developing RA.
It is important to note that previous research has illustrated a role for anti-RHF autoantibodies as enhancers of bone loss in the presence of anti-CCP autoantibodies [116].
Organizing pneumonia with a positive result for anti-CCP antibodies as the first clinical presentation of rheumatoid arthritis.
On the other hand, positive anti-CCP antibody has 98% specificity for diagnosis of the disease.
Based on this knowledge, the aim of our study was to investigate the association of PTPN22 haplotypes (-1123G>C/+1858C>T) with RA and their relationship with anti-CCP antibodies in patients from Western Mexico.
The elevated IL-34 in serum has been observed in RA patients, which is associated with radiographic progression, RF, and anti-CCP antibody titers [20, 21].
Anti-CCP levels of remission group compared to MDAG were different, but not statistically significant (p=0.071).
The presence of anticyclic citrullinated peptide (anti-CCP) antibodies was detected using an enzyme-linked immunosorbent assay, and antinuclear antibodies (ANAs) were detected by immunofluorescence.