nonsteroidal anti-inflammatory drug

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nonsteroidal anti-inflammatory drug,

a drug that suppresses inflammation in a manner similar to steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
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, but without the side effects of steroids; commonly referred to by the acronym NSAID (ĕn`sĕd). Also effective in alleviating pain and fever, NSAIDs are commonly used to treat the symptoms of arthritis, gout, bursitis, painful menstruation, and headache. They act by inhibiting the synthesis of prostaglandins, leukotrienes, and other compounds that are involved in the inflammatory process.

Aspirin is technically an NSAID, but the term is often used to refer to nonaspirin products. The first nonaspirin NSAIDs were introduced in 1964. Common NSAID products include diclofenac (Cataflam, Voltaren), indomethacin (Indocin), ketorolac (Acular, Toradol), and piroxicam (Feldene). Ibuprofenibuprofen
, nonsteroidal anti-inflammatory drug (NSAID) that reduces pain, fever, and inflammation. Along with naproxen and ketoprofen, ibuprofen belongs to the propionic acid class of NSAIDs. It was first made available in 1967.
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, naproxennaproxen
and naproxen sodium,
potent nonsteroidal anti-inflammatory drugs (NSAID) used to alleviate the minor pain of arthritis, menstruation, headaches, and the like, and to reduce fever.
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, and ketoprofenketoprofen
, nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and fever-reducing effects, used to relieve the symptoms of headaches, arthritis, and painful menstruation.
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 are available as over-the-counter drugs in the United States. The cox-2 inhibitors, such as celecoxib (Celebrex), selectively inhibit clooxygenase-2 (cox-2), an enzyme that causes pain and inflammation in arthritic joints, but do not interfere with cox-1, which protects the stomach and intestinal lining from ulceration. Very common drugs, NSAIDs are taken daily by an estimated 3 million Americans.

Although they are often considered easier to tolerate than aspirin, and most do not have as strong an anticlotting effect as aspirin, NSAIDS can have serious side effects, particularly gastrointestinal ulcers and upper gastrointestinal tract bleeding and perforation in those who take the drugs on a regular basis. NSAID-related gastropathy results in more than 2,000 deaths in the United States each year.

References in periodicals archive ?
Keep in mind that if you are not eating these and other anti-inflammatory foods on a consistent basis, you may want to consider supplementing the diet with some of these antiinflammatory compounds.
This study provides a good insight into the possible mechanisms behind the anti-inflammatory effect of the flavonoid vitexin, and, of note, is the first study to demonstrate its multi-target activity through inhibition of leukocyte migration, particularly the neutrophils, and through inactivation of three pro-inflammatory pathways which may lead to inhibition of inflammatory cytokines, NO and PGE2release.
Hence in view of these inconclusive results, it is not clear whether salbutamol had anti-inflammatory activity in acute pain management.
Hoppe recommends chamomile, too, as a mild anti-inflammatory.
This anti-inflammatory enzyme (serratiopeptidase) inhibits the formation of these pain inducing amines.
The 32-year old researcher from the Dermatology and Allergology Clinic at Charite and Berlin-Brandenburg School for Regenerative Therapies, and her colleagues identified the basic signals that contribute to whether or not a pathogenic or anti-inflammatory immune cell develops.
Lev-Ari and his colleagues found that Celecoxib, a popular anti-inflammatory drug commonly used to treat arthritis, also inhibits proliferation of colon cancer in laboratory settings.
Although a number of different synthetic and semi synthetic drugs are in use today to combat with inflammation, there has always been a thirst to search for the natural anti-inflammatory constituents from spices and herbs.
Cod liver oil supplements can offer a natural pain management treatment without the harmful side effects that can be associated with anti-inflammatory drugs.
All tetracyclines have anti-inflammatory activity, he said, but doxgcgcline is the only one for which investigators have separated anti-inflammatory from antibiotic dosing.
All tetracyclines have anti-inflammatory activity, he said, but doxycycline is the only one for which investigators have separated anti-inflammatory from antibiotic dosing.
Among poultice preparations containing nonsteroidal anti-inflammatory drugs (NSAIDs), it is the first poultice for usage once per day to be granted approval for manufacture.