antibody binding site

[¦an·tə‚bäd·ē ′bīnd·iŋ ‚sīt]

(cell and molecular biology)

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If the amino acids in this stem antibody binding site prove to be so important to the structure of hemagglutinin that the virus can't tolerate change there, then the virus wouldn't be able to adapt to and mutate away from a vaccine targeting this site via stimulation of neutralizing antibodies.

Progress toward universal influenza vaccines

This mechanism of action has been validated by experiments with single-chain antibody fragments containing the antibody binding site (15).

Passive antibody administration (immediate immunity) as a specific defense against biological weapons. (Perspective)

The new patent is much broader and now claims the use of any antibody that recognizes or binds to the epitope, an antibody binding site on the TpP protein, that is recognized by MH-1 or 45J.

American Biogenetic secures two new United States patents on TpP diagnostic test

The changes turn out to be on the virus surface, suggesting very strongly, says Hogle, "that the site of the mutation represents the antibody binding site."

Picturing polio

This [K.sub.D1] value, 9.52 nmol/L, was taken as a measure for the affinity of 1 antibody binding site. The quality of the fitting analysis was indicated by a [chi square] value of 7.8.

Biosensor analysis of [beta]2-glycoprotein I-reactive autoantibodies: evidence for isotype-specific binding and differentiation of pathogenic from infection-induced antibodies

The latter has facilitated the development of light-scattering assays for haptens and other relatively low-molecular-mass analytes (<5000 Da and only providing one viable antibody binding site per molecule) by using the principle of immunoinhibition [5].

Kinetics and proposed mechanism of the reaction of an immunoinhibition, particle-enhanced immunoassay

The endogenous T3 competes with the labeled analogue T3 for capture antibody binding sites. In contrast to sandwich assays, the signal is inversely proportional to the concentration of the analyte such as T3.

Strategies for combating biotin interference: what do labs need to know--and do?

This high dose saturated the antibody binding sites and induced falsely increased results in the competition assays for free triiodothyronine and free thyroxine and lower results in the sandwich method for thyroid-stimulating hormone.

Consistent, but Totally Misleading, Thyroid Function Test Results. (What Is Your Guess?

First, the sections were treated with I-Block (Tropix) to block any unspecific antibody binding sites. Then anti-DIG-antibody was added and the sections were incubated overnight at 4 C.

Ultrapure water drives RNA technologies: the use of ultrapure water in RNA research using in situ hybridization ensures contamination-free, reliable results

Identification of canary grass (Phalaris aquatic) pollen allergens by immunoblotting: IgE and IgG antibody binding sites; Allergy 1993; 48: 273-281

Immunological characterization of immunoglobulin G towards house dust allergens

Practically, if one uses antibodies with known MESF values, which are assigned using the same methodology for obtaining MESF values of beads, the number of antibody binding sites per cell is equal to the ratio of the MESF value per cell and the MESF value per antibody.

Quantitating fluorescence intensity from fluorophores: practical use of MESF values

These biosensors can be applied for direct detection or in a competitive immuno-biosensor format where a labeled antigen competes with the analyte for the antibody binding sites. The antibodies can be immobilized on fibre optic probes used in fluorescence-based systems or using surface plasma resonance, etc.

Recent Advances in Biosensor Research for Environmental Applications

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