antibody-dependent cell-mediated cytotoxicity


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Related to antibody-dependent cell-mediated cytotoxicity: antibody-dependent cell-mediated cytotoxicity (ADCC)

antibody-dependent cell-mediated cytotoxicity

[‚ant·i‚bäd·ē di¦pen·dənt ‚sel¦mēd·ē‚ād·əd ‚sī·tō·täk′sis·əd·ē]
(immunology)
An immunologic response in which an immunologic effector cell binds to a target cell coated with antibodies, triggering a series of metabolic events that leads to lysis of the target cell.
References in periodicals archive ?
By retaining a native Fc-region, avelumab is thought to potentially engage the innate immune system and induce antibody-dependent cell-mediated cytotoxicity (ADCC).
Berne, "Antibody-dependent cell-mediated cytotoxicity tests for immunosuppression monitoring of transplant patients," Transplantation, vol.
Avelumab has also been shown to induce NK cell-mediated direct tumor cell lysis via antibody-dependent cell-mediated cytotoxicity in vitro.
Wick, "Endothelial cell apoptosis in systemic sclerosis is induced by antibody-dependent cell-mediated cytotoxicity via CD95," Arthritis & Rheumatism, vol.
Using Xencor's XmAb Fc enhancement technology, MOR208 has been engineered to possess significantly enhanced antibody-dependent cell-mediated cytotoxicity (ADCC), thus improving a key mechanism for tumour cell killing and offering potential for enhanced efficacy compared to traditional antibodies for the treatment of cancer.

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