antibody-dependent cell-mediated cytotoxicity

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Related to Antibody-dependent cellular cytotoxicity: antibody-dependent cell-mediated cytotoxicity (ADCC)

antibody-dependent cell-mediated cytotoxicity

[‚ant·i‚bäd·ē di¦pen·dənt ‚sel¦mēd·ē‚ād·əd ‚sī·tō·täk′sis·əd·ē]
(immunology)
An immunologic response in which an immunologic effector cell binds to a target cell coated with antibodies, triggering a series of metabolic events that leads to lysis of the target cell.
References in periodicals archive ?
We have previously shown that the same gE epitope is involved in both complement-dependent neutralization (12) as well as antibody-dependent cellular cytotoxicity (13).
The product candidate is derived from a master iPSC line engineered to express three functional anti-tumor components: a proprietary CAR targeting the B-cell antigen CD19; a novel hnCD16 Fc receptor for augmented antibody-dependent cellular cytotoxicity and a unique IL-15 receptor fusion for enhanced NK cell activity.
FPA150 is a novel B7-H4 antibody that possesses both T cell immune checkpoint blockade and antibody-dependent cellular cytotoxicity activities.
DSA also facilitated NK cellmediated antibody-dependent cellular cytotoxicity (ADCC) in an IFN[gamma] and cell-contact dependent manner [110].

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