Either newly diagnosed cases of generalized epilepsy without antiepileptic
treatment or known cases of generalized epilepsy on carbamazepine monotherapy were included in the study along with the age and gender matched healthy subjects as controls.
Herzog and his associates examined the frequencies of seizure outcomes on hormonal and nonhormonal contraceptives stratifying by type of antiepileptic
drug women used when starting a particular contraceptive method.
drugs therapy in elderly requires pharmacokinetics and pharmacodynamic adjustment due to the physiological changes associated with aging and frequent co-morbid conditions.
Mothers who had epilepsy provided data about the use of antiepileptic
drugs during pregnancy and breastfeeding.
The agency is asking physicians to encourage their pregnant patients on valproate to enroll in the North American Antiepileptic
Drug Registry online or at 888-233-2334.
It is believed to exert its antiepileptic
effects by regulating activity of sodium channels in the brain that carry excessive electrical charges thought to cause seizures, so as to prolong their inactive state.
Being uninsured or having Medicaid coverage was associated with about 50% lower odds for receiving counseling for bone health among women on phenytoin, carbamazepine, or phenobarbital-older antiepileptic
drugs that are known to increase bone turnover and cause other bone issues that are especially problematic for women--investigator and second-year medical student Katie Paniszyn reported at the meeting.
treatment and risk for hepatobiliary cancer and malignant lymphoma.
An additional study offered preliminary insight into the antiepileptic
drug's (AED) safety as adjunctive therapy for patients with primary generalized tonic-clonic seizures (PGTCS), UCB said.
direct effects on bone cells, intestinal calcium transport and resistance to parathyroid hormone, rather than monocausally by decreased serum 25-OHVD [17, 35, 36], In some recent studies, genetic variation was shown to have some effects as reducing bone mineral density and active vitamin D metabolism in epilepsy patients receiving antiepileptic
drugs [37, 38], In conclusion, a statistically significant alteration has not been observed in biomarkers of bone formation and resorption in healthy rats receiving carbamazepine, Studying the effects of carbamazepine in healthy animals enabled elimination of some confounding factors affecting bone metabolism (e.
Within the subgroup with WWE risk of malformations were higher for those who were not on antiepileptic
drugs and those who were on polytherapy.
Now, a team of researchers, led by Detlev Boison, at the Legacy Research Institute, Portland, has identified in mice the molecular mechanism responsible for the antiepileptic
effects of the ketogenic diet.