antagonist

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antagonist

1. any muscle that opposes the action of another
2. a drug that counteracts the effects of another drug
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

antagonist

[an′tag·ə‚nist]
(biochemistry)
A molecule that bears sufficient structural similarity to a second molecule to compete with that molecule for binding sites on a third molecule.
(pharmacology)
A drug or other chemical substance capable of reducing the physiological activity of another chemical substance; refers especially to a drug that opposes the action of a drug or other chemical substance on the nervous system by combining with and blocking the nerve receptor.
(physiology)
A muscle that contracts with, and limits the action of, another muscle, called an agonist, with which it is paired.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
2-(R)-benzylaminoquinoxalines as nonclassical antifolate agents: synthesis and evaluation of in vitro anticancer activity," Farmaco, vol.
Oliveras-Ferraros et al., "Metabolomic fingerprint reveals that metformin impairs one-carbon metabolism in a manner similar to the antifolate class of chemotherapy drugs," Aging, vol.
LY231514, a pyrrolopyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
This friendship proved to be important -- during his research on folic acid, Rao had stumbled upon antifolates, the dream chemical Farber had been fantasising about.
Concerns have been raised that intake of folic acid might cause harmful effects, including progression of nerve damage in B12-deficient persons; excess intake in children; accumulation of unmetabolized folic acid; blunting of antifolate therapy (methotrexate and phenytoin); accelerated cognitive decline in the elderly; epigenetic hypermethylation; and cancer promotion (11).
(19,20) MTX acts as a folate antagonist, and most of the adverse effects of MTX are related to the antifolate activity which may mimic symptoms of folate deficiency.
Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance.
The drug is a selective antifolate designed to accumulate preferentially in cancer cells.
"We are pleased that our long-term medicinal chemistry program in the area of antifolate therapeutic agents has resulted in development of a clinically effective drug for treatment of certain types of human cancer," stated Joseph DeGraw, Ph.D., and William Colwell, Ph.D., both formerly of SRI International.
In this trial, tumour expression of TS, DPD and gamma-glutamyl hydrolase, related to antifolate resistance [7], did not condition RR in both arms.