antigen presentation


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Related to antigen presentation: clonal expansion, antigen recognition

antigen presentation

[¦an·tə·jən ‚prē·zən′tā·shən]
(immunology)
The process whereby a cell expresses antigen on its surface in a form that can be recognized by a T lymphocyte.
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It is conceivable that dormant bacteria reside in cells which have a scarce ability to act as antigen presentation cells, and subverted macrophages in mature granulomas.
It was evident that when TLR3 (poly I:C ligand) or TLR7/8 (resiquimod ligand, R-848) were used, concomitant signaling of DCs led to efficient antigen presentation by MR targeting [58].
HSPs); d) employment of chemotherapy-induced apoptotic cell death to increase the number of antigen-loaded DCs (76), 2) improving antigen expression, processing, and presentation in DCs including a) codon optimization as a strategy to enhance antigen expression in DCs; b) employment of intracellular targeting strategies to enhance MHC class I and class II antigen presentation in DCs (e.g.
understanding the mechanisms of DNA uptake and antigen presentation and
And although crystallographic pictures of the MHC-I molecule don't lead directly to new vaccines, knowing the basic chemical rules of antigen presentation to the immune system is important.
In addition to classical MHC I-restricted endogenous antigen presentation, cross-presentation allows dendritic cells (DC) presenting extracellular antigen and inducing protective immunity against intracellular microbe infection and tumors [6-8].
The company's peptide- or nucleic acid-based immunotherapeutic products comprise multiple naturally processed epitopes designed to comprehensively stimulate a patient's killer T cells and helper T cells, and to restore or further augment antigen presentation by using proprietary nucleic acid-based expression systems.
One of these checkpoints is antigen presentation, which is accomplished primarily by mature dendritic cells.
Here, we demonstrate that gonococcus conditions macrophage cell line phenotype and its functionality, producing a shift towards anti-inflammatory cytokine production, inefficient upregulation in molecules involved in antigen presentation and T-cell activation, and weak allogeneic T-cell stimulatory activity.
The technology uses the patient's own B cells for antigen production as well as for antigen presentation.
BACKGROUND: Dysregulation of positive and negative selection, antigen presentation, or apoptosis in the thymus can lead to immunosuppression or autoimmunity.
Chapter 11 describes the charcteristics of a good vaccine; chapter 12 the use of HPV peptide based vaccine in stimulating the dendritic cells; chapter 14 deals with the use of modified adenoviral vectors in combination with GM-CSF and IL-4 in enhancing antigen presentation by dendritic cells; chapter 19 shows the usefulness of Mycobacterium inicus pranii as vaccine for head and neck cancers.