antigen presentation


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Related to antigen presentation: clonal expansion, antigen recognition

antigen presentation

[¦an·tə·jən ‚prē·zən′tā·shən]
(immunology)
The process whereby a cell expresses antigen on its surface in a form that can be recognized by a T lymphocyte.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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It is conceivable that dormant bacteria reside in cells which have a scarce ability to act as antigen presentation cells, and subverted macrophages in mature granulomas.
It was evident that when TLR3 (poly I:C ligand) or TLR7/8 (resiquimod ligand, R-848) were used, concomitant signaling of DCs led to efficient antigen presentation by MR targeting [58].
HSPs); d) employment of chemotherapy-induced apoptotic cell death to increase the number of antigen-loaded DCs (76), 2) improving antigen expression, processing, and presentation in DCs including a) codon optimization as a strategy to enhance antigen expression in DCs; b) employment of intracellular targeting strategies to enhance MHC class I and class II antigen presentation in DCs (e.g.
understanding the mechanisms of DNA uptake and antigen presentation and
And although crystallographic pictures of the MHC-I molecule don't lead directly to new vaccines, knowing the basic chemical rules of antigen presentation to the immune system is important.
In addition to classical MHC I-restricted endogenous antigen presentation, cross-presentation allows dendritic cells (DC) presenting extracellular antigen and inducing protective immunity against intracellular microbe infection and tumors [6-8].
The company's peptide- or nucleic acid-based immunotherapeutic products comprise multiple naturally processed epitopes designed to comprehensively stimulate a patient's killer T cells and helper T cells, and to restore or further augment antigen presentation by using proprietary nucleic acid-based expression systems.
Here, we demonstrate that gonococcus conditions macrophage cell line phenotype and its functionality, producing a shift towards anti-inflammatory cytokine production, inefficient upregulation in molecules involved in antigen presentation and T-cell activation, and weak allogeneic T-cell stimulatory activity.
The technology uses the patient's own B cells for antigen production as well as for antigen presentation.
BACKGROUND: Dysregulation of positive and negative selection, antigen presentation, or apoptosis in the thymus can lead to immunosuppression or autoimmunity.
Chapter 11 describes the charcteristics of a good vaccine; chapter 12 the use of HPV peptide based vaccine in stimulating the dendritic cells; chapter 14 deals with the use of modified adenoviral vectors in combination with GM-CSF and IL-4 in enhancing antigen presentation by dendritic cells; chapter 19 shows the usefulness of Mycobacterium inicus pranii as vaccine for head and neck cancers.