It is conceivable that dormant bacteria reside in cells which have a scarce ability to act as antigen presentation
cells, and subverted macrophages in mature granulomas.
It was evident that when TLR3 (poly I:C ligand) or TLR7/8 (resiquimod ligand, R-848) were used, concomitant signaling of DCs led to efficient antigen presentation
by MR targeting .
HSPs); d) employment of chemotherapy-induced apoptotic cell death to increase the number of antigen-loaded DCs (76), 2) improving antigen expression, processing, and presentation in DCs including a) codon optimization as a strategy to enhance antigen expression in DCs; b) employment of intracellular targeting strategies to enhance MHC class I and class II antigen presentation
in DCs (e.g.
understanding the mechanisms of DNA uptake and antigen presentation
And although crystallographic pictures of the MHC-I molecule don't lead directly to new vaccines, knowing the basic chemical rules of antigen presentation
to the immune system is important.
In addition to classical MHC I-restricted endogenous antigen presentation
, cross-presentation allows dendritic cells (DC) presenting extracellular antigen and inducing protective immunity against intracellular microbe infection and tumors [6-8].
The company's peptide- or nucleic acid-based immunotherapeutic products comprise multiple naturally processed epitopes designed to comprehensively stimulate a patient's killer T cells and helper T cells, and to restore or further augment antigen presentation
by using proprietary nucleic acid-based expression systems.
One of these checkpoints is antigen presentation
, which is accomplished primarily by mature dendritic cells.
Here, we demonstrate that gonococcus conditions macrophage cell line phenotype and its functionality, producing a shift towards anti-inflammatory cytokine production, inefficient upregulation in molecules involved in antigen presentation
and T-cell activation, and weak allogeneic T-cell stimulatory activity.
The technology uses the patient's own B cells for antigen production as well as for antigen presentation
BACKGROUND: Dysregulation of positive and negative selection, antigen presentation
, or apoptosis in the thymus can lead to immunosuppression or autoimmunity.
Chapter 11 describes the charcteristics of a good vaccine; chapter 12 the use of HPV peptide based vaccine in stimulating the dendritic cells; chapter 14 deals with the use of modified adenoviral vectors in combination with GM-CSF and IL-4 in enhancing antigen presentation
by dendritic cells; chapter 19 shows the usefulness of Mycobacterium inicus pranii as vaccine for head and neck cancers.