The classification of antigenic determinants
into epitopes and nonepitopes ignoring the antigen reconfiguration in Ag-Ab complex may not accurately reflect biological reality .
The [Centocor.sup.R] CA 72-4[TM} assay (Fujirebio Diagnostics, Inc./Centocor, Inc.) is a solid phase radioimmunoassay (CA 72-4) (RIA) based on two monoclonal antibodies, cc49 and B72.3, which react with distinct antigenic determinants
on a tumor associated glycoprotein TAG 72.
coli and the antiserum containing the F18 specific antigenic determinant
"a" were mixed and the agglutination reaction was observed.
Focusing on the epitope information, using N protein-specific mAbs we thoroughly mapped the antigenic determinants
distributed on the SARS-CoV N protein.
Despite the extensive use of PSA as a clinical marker of prostate cancer, much is yet to be learned about the antigenic determinants
on the PSA molecule (15).
Cross-reactivity experiments indicated that the amino acid sequence -Xaa-Pro-Thr-COON (where Xaa is a basic amino acid) at B28-B30 is the antigenic determinant
. First, modifications to this region produced the greatest disruption in antigenicity (Table 1), and native human insulin displays cross-reactivity.
(12.) Kolaskar, A.S., Tongaonkar, P.C., A semiempirical method for prediction of antigenic determinants
on protein antigens.
This base could expose the sugar epitopes, leaving them available as antigenic determinants
to induce specific IgE production [4,9].
In Figure 7(1B), the two peaks of antigenicity are located on the surface of the protein with higher score in green color and, additionally, its active center in red color is observed, corresponding to the information registered on the antigenic determinants
in Table 5.
Prediction of Antigenic Determinants
and Peptide Synthesis.
Recombinant core particles of hepatitis B virus exposing foreign antigenic determinants
on their surface.
Full length Hexon carries type, group and subgroup specific antigenic determinants
, whereas, hypervariable region of hexon contains type specific antigenic regions.