antigenic determinant


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Related to antigenic determinant: hapten, Clonal selection

antigenic determinant

[‚an·tə¦jen·ik di′tər·mə·nənt]
(immunology)
The portion of an antigen molecule that determines the specificity of the antigen-antibody reaction.
References in periodicals archive ?
Antibody responses to antigenic determinants of influenza virus hemagglutinin.
Thomas Jefferson University (Philadelphia, PA) has patented live, attenuated recombinant rabies virus vaccines generated using reverse genetics to combine the antigenic determinants that render the rabies virus non-pathogenic with the determinants that are responsible for the elicitation of an effective anti-rabies immune response.
Antibodies with specific recognition for specific antigenic determinants could now be prepared.
This property is especially critical during human pandemics that are characterized by novel antigenic determinants.
The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants unique to either allelic protein product.
To compare with IAPP immunoreactivity measured by another assay detecting different antigenic determinants, the same samples were assayed by the solid amylin enzyme immunoassay (Amylin Pharmaceuticals Inc) without extraction (4).
To explain the low sensitivity, it must be considered that anti-CCP antibodies are a heterogeneous group of antibodies directed against different epitopes on the citrulline molecule, that each patient's serum contains different subsets of antibodies, and that the synthetic peptide used in this assay represents a relatively small set of antigenic determinants that do not entirely encompasses the antigenic determinants present on the as yet unknown antigenic molecule in the joint (14).