antigenic drift


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Related to antigenic drift: Original antigenic sin

antigenic drift

[‚an·tə¦jen·ik ′drift]
(immunology)
Minor change of an antigen on the surface of a pathogenic microorganism.
References in periodicals archive ?
Antigenic drift occurs because of the accumulation of point mutations that eventually results in amino acid substitutions.
Mutation from arginine to lysine at the position 189 of hemagglutinin contributes to the antigenic drift in H3N2 swine influenza viruses.
Antigenic drift results from relatively minor changes in the viral genome.
Antigenic Drift Will Not Pose a Problem for NanoViricides' Drugs, says Company
This form of influenza tends to undergo both the antigenic drift as well as the antigenic shift.
We found no evidence of substantial antigenic drift in circulating viruses that could affect seroepidemiology results (online Technical Appendix Table).
One reason that it has been difficult to assess health risks associated with the influenza vaccine is that the vaccine's components can change from year to year in response to antigenic drift.
This could be necessary if antigenic drift reduces the effectiveness of the vaccine recently announced as being in development at GlaxoSmithKline (NYSE:GSK) or flu vaccines in the pipeline at French-based Sanofi Aventis (NYSE:SNY).
The recent increase in scarlet fever notifications might be attributable to antigenic drift, increase in virulence of GAS (8), or increased circulation of GAS.
Given the mutations and antigenic drift, because of which vaccines will always have limited effectiveness in control, new treatments such as ours, will be essential.
In 2004, further antigenic drift occurred away from this vaccine strain (30) which may explain the continuing increased mortality in 2004, despite the apparently low level of influenza circulation generally.