antigenic variation


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antigenic variation

[‚an·tə¦jen·ik ‚ver·ē′ā·shən]
(immunology)
Alteration of an antigen on the surface of a microorganism; may enable a pathogenic mocroorganism to evade destruction by the host's immune system.
References in periodicals archive ?
In campylobacter, antigenic variation of Surface layer proteins (SLPs) is the result of homologous recombination that leads to its antigenic variation.
falciparum is the var gene family which encodes PfEMP1, a protein that is exported to the 'knob like' binding structures on the surface of infected erythrocytes with a key role in antigenic variation and cytoadherence (12).
The virus undergoes antigenic variation year by year due to the selection of antigenic variants by immunological pressure of the hosts.
The persistence of the rickettsia in the infected host seems to be a consequence of the antigenic variation of the parasite observed during A.
Antigenic variation at site 1 of type C viruses is often based on alternate switching between alanine and threonine residues without accumulation of amino acid substitutions (14).
The prevalence of gastrointestinal parasitism caused by these helminths is continuously increasing and the reason of increasing gastrointestinal parasitism is their antigenic variation. With the help of antigenic variation, parasites can evade host immune response.
The text blends classical and medical parasitology with more modern disciplines, discussing the molecular and immunological basis for pathogenesis, metabolic pathways, and antigenic variation for the protozoan pathogens.
(*) A fourfold or greater difference in hemagglutination-inhibition titers between two viruses is indicative of antigenic variation between viruses.