Anthelmintic

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anthelmintic

[¦an·thel¦min·tik]
(pharmacology)

Anthelmintic

 

(also vermifuge, helminthagogue), a preparation used to treat worm diseases, or helminthiases. The action of different anthelmintics varies. Some preparations, such as Heptylresorcine and Phenasal, damage the cuticle (integument) of helminths, while other preparations, such as santonin, ditrazin, piperazine, and naphtammone, alter the tone and mobility of parasites. Anthelmintics expel helminths from the patient’s body and are used when helminths infest the intestine and its communicating organs (liver, pancreas). Anthelmintics are also used to kill helminths.

Piperazine acts on the neuromuscular system of ascarids, which are subsequently excreted with feces. Phenasal destroys the integument of various tapeworms, including beef tapeworms, dwarf tapeworms, and broad tapeworms. They are then digested in the intestine and their residue is excreted. Chloxyl kills Siberian liver fluke in the liver and pancreas. The parasite is then eliminated into the intestine. Other anthelmintics, such as ditrazin and antimony preparations, destroy helminths, such as filiariae and schistosomes, in the blood, lymphatics, and tissues. Some antihelmintics, such as ditrazin and Chloxyl, are produced chemically. Others are obtained from plants, for example, from Artemisia cina or the extract of male fern.

REFERENCE

Krotov, A. I. Osnovy eksperimental’noi terapii gel’mintozov. Moscow, 1973.

N. N. PLOTNIKOV

References in periodicals archive ?
FAMACHA[c] system could be useful in animals highly infected by Haemonchus, but parasitological methods are also required to evaluate and apply antihelmintic treatments.
Patients treated with complete surgical resection or biopsy and antihelmintic medication (Praziquantel or Oxamniquine) normally have a good outcome (2).
TTHF (500 mg) contained 7 plant species as mentioned above used for antihelmintic formulae in this experiment.
The dose of this drug in cattle for oral and subcutaneous administration is 0.2mg/Kg and for pour on administration is 0.5mg/Kg; these doses of Ivermectin have importance antihelmintic effect between 97-100% on adult form and [L.sub.4] (forth stage of larvae) of Haemonchus, Ostertagia, Cooperia, Trichostrongylus, Strongyloides, Bonostomum, Nematodirus, Trichuris, Oesophagostomum, Dictyocaulus and Chabertia ovina, also with these doses have effective role in reduce of some arthropods [11,14,20,24,25].
For this reason, anthelmintics are highly utilized, often as the only strategy for the control of GIN, which has resulted in the development of antihelmintic resistance (FAO 2003, Fleming et al.
Capparis species has been reported to have antihelmintic, anti microbial and anti inflammatory activities (17), (18).
The plant is used in the pharmaceutical industry for its anti-inflammatory, antiasthmatic, antispasmodic and antihelmintic properties (Mino et al.
(1999) "Traditional antihelmintic, antiparasitic and repellent uses of plants in central Italy".
Schiff bases are compounds that are easily synthesized and many of Schiff bases in general are found to possess physiological biological and pharmaceutical activities such as antibacterial, antidiabetic, antihelmintic and antidepressant [1-5].
14) extraction Metronidazole (anti-inflammatory more than antihelmintic) Wound care Cutaneous Praziquantel 40 schistosomiasis mg/kg/day stat Sometimes repeated Systemic steroids in Katayama fever Avoidance of water in endemic areas Snail control Trypanosomiasis Nifurtimox (with gamma interferon Suramin, pentamidine Eflornithine WHO control measures Filarial Ivermectin elephantiasis Adjunctive albendazole, doxycycline Surgical correction DEC = diethylcarbamazine; ANS = autonomic nervous system; GIT = gastrointestinal; CVS = cardiovascular system; CSF = cerebrospinal fluid; PCR = polymerase chain reaction.
Treatment of biliary ascariasis infection is with antihelmintic medication, endoscopic or surgical extraction [6].