The common contraindications of rapid-acting antihypertensive agents
are shown in Table 1.
Unfortunately, there is still a paucity of data to determine which antihypertensive agent
is preferred in this setting.
Which classes of antihypertensive agents
have been studied in randomized trials examining patients with hypertension on hemodialysis?
The mean (+- SE) scores for domain of the erectile function (five questions; possible total score, 1 to 30) for 100 men in sildenafil group than the placebo group for both patients taking and those not taking antihypertensive agents
is presented in figure-1.
Dual-acting combination drugs have been developed because of the frequent need for two different types of antihypertensive agents
to control blood pressure.
(19, 20) In the ALLHAT study, 60% of those whose BP was controlled to target (< 140/90 mmHg) received two or more antihypertensive agents
. Only 30% were controlled on one drug.
Factors associated with failure to obtain an antihypertensive prescription fell into 3 categories: history of hypertension (new vs existing diagnosis), formulary status of antihypertensive agent
, and type of health plan.
Friedman noted in his editorial, the recommendation that such women should switch to a different antihypertensive agent
is undercut by the lack of safety data on any of these drugs.
For a hypertensive emergency the patient is admitted to the intensive care unit for continuous monitoring, and given a fast-acting, intravenous (IV) antihypertensive agent
. The goal is to reduce mean arterial blood pressure to an adequate level, avoiding excessive falls that may precipitate renal, cerebral or coronary ischemia.[6,11] Monitoring the patient's neurological status in relation to the MAP is important to maintain an adequate cerebral perfusion.
An elderly patient who has not responded to a single agent should be asked about any other medications (or substances) that might be interfering with the antihypertensive agent
, especially NSAIDs, tricyclic antidepressants, sympathomimetics, and caffeine.
VIENNA -- Mecamylamine, an old, rarely prescribed, truly obscure antihypertensive agent
, may be favorably reincarnated as an antidepressant with a completely novel mechanism of action--and vastly greater potential use.
In particular, they have been co-promoting Livalo Tab (antihypercholesterolemic agent) and Olmetec Tablets (antihypertensive agent
) in Japan.