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A drug, such as quinacrine, that prevents or suppresses malaria.
Acting against malaria.



a medicinal preparation for the treatment and prophylaxis of malaria. Antimalarials are classified into several groups according to their selective or predominant effect on various forms of plasmodia. For example, quinacrine hydrochloride, chloroquine, and quinine kill schizonts in the blood and rapidly curtail malarial attacks, while quinocide and primaquine destroy malarial parasites in tissues and prevent future relapses of tertian and quartan malaria. For this reason, drugs of both groups are usually used with the above forms of malaria. Proguanil hydrochloride acts on the erythrocytic and sexual forms of plasmodia; it is especially effective against the pathogen that produces falciparum malaria. Quinocide and primaquine also kill the gamonts of pathogens and, as a result, the infected person remains noninfective for the mosquito. Quinine is usually used in regions where the pathogens that produce falciparum malaria are resistant to chloroquine. The administration of antimalarials, such as chloroquine, to healthy individuals is used in the chemoprophylaxis of malarial foci.

Most antimalarials are obtained synthetically. Quinine, for example, is an alkaloid of a cinchona tree. Antimalarials are also used to treat certain diseases caused by protozoans or helminths; for example, quinacrine hydrochloride is used to treat amebiasis, giardiasis, and leishmaniasis, while pyrimethamine is used to treat toxoplasmosis.


Moshkovskii, Sh. D., ed. Ukazaniia po lecheniiu i khimioprofilaktike maliarii. Moscow, 1972.


References in periodicals archive ?
AQ [3] is a potent antimalarial drug but side effects of hepatotoxicity and agranulocytosis have limited its use.
The number of reports assessing levels of Plasmodium falciparum resistance to antimalarial drugs since the introduction of ACT in Senegal has been limited.
The researchers said that they hope to adapt the iPSC-derived liver cells to scalable, high-throughput culture formats to support fast, efficient antimalarial drug screens.
The sequestration of parasitized RBCs in the pulmonary microcirculation may initiate lung damage via direct endothelial activation and recruitment of host inflammatory responses, which can continue after treatment with antimalarial drugs.
To design a novel antimalarial drug compound various drug databases such as Drug Bank (http://www.
Antimalarial drug resistance across SA and neighbouring countries
For optimal function of Antimalarial drug in bioavailibilitas conditions, the solvent must be considered.
Unfortunately, continuous and frequent treatments with antimalarial drugs, such as chloroquine, have induced parasite resistance (Baird 2004), reinforcing the need for finding more natural antimalarial components.
Antimalarial Drug Combination Therapy: Report of a WHO Technical Consultation.
Bate R, Coticelli P, Tren R, Attaran A: Antimalarial Drug Quality in the Most Severely Malarious Parts of Africa--A Six Country Study, PLoS One.
To further malaria management, the monitoring of antimalarial drug resistance is of critical importance for the national Malaria Control Programme.
launches Antimalarial drug 'ARH 1' developed with innovative dose optimization technology, for the first time in the world Lucknow- Lincoln Pharmaceuticals Ltd.