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A drug, such as quinacrine, that prevents or suppresses malaria.
Acting against malaria.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a medicinal preparation for the treatment and prophylaxis of malaria. Antimalarials are classified into several groups according to their selective or predominant effect on various forms of plasmodia. For example, quinacrine hydrochloride, chloroquine, and quinine kill schizonts in the blood and rapidly curtail malarial attacks, while quinocide and primaquine destroy malarial parasites in tissues and prevent future relapses of tertian and quartan malaria. For this reason, drugs of both groups are usually used with the above forms of malaria. Proguanil hydrochloride acts on the erythrocytic and sexual forms of plasmodia; it is especially effective against the pathogen that produces falciparum malaria. Quinocide and primaquine also kill the gamonts of pathogens and, as a result, the infected person remains noninfective for the mosquito. Quinine is usually used in regions where the pathogens that produce falciparum malaria are resistant to chloroquine. The administration of antimalarials, such as chloroquine, to healthy individuals is used in the chemoprophylaxis of malarial foci.

Most antimalarials are obtained synthetically. Quinine, for example, is an alkaloid of a cinchona tree. Antimalarials are also used to treat certain diseases caused by protozoans or helminths; for example, quinacrine hydrochloride is used to treat amebiasis, giardiasis, and leishmaniasis, while pyrimethamine is used to treat toxoplasmosis.


Moshkovskii, Sh. D., ed. Ukazaniia po lecheniiu i khimioprofilaktike maliarii. Moscow, 1972.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Liver damage is caused by high concentration of ALT/AST in the serum which may be caused by different antimalarial drugs like, quinine and chloroquine etc., (Pari, and Amali, 2005; Farombi et al., 2000; Debra and Megan, 1999).
The antimalarial drugs used for this study were (2E)-3-(4-dimethylamino-phenyl)-1-(4imidazol-1-yl-phenyl) prop-2-en-1-one) (C1) and (1E,4E)-1-[4-(dimethylamino) phenyl] 5-(4-methoxyphenyl)-1,4-pentadiene-3- one) (C2).
Based on the total number of 6667 prescriptions containing at least one antimalarial drug after excluding those from antenatal clinic, a sampling interval of 20 was calculated and simple balloting was used for the first pick.
The spread of resistance to current antimalarial drugs have prompted investigators and pharmaceutical companies to focus on the development of new antimalarial drug.
Furthermore, unregulated and irrational use of antimalarial drug use as well as counterfeit and poor quality medicines dispensed in Africa and other parts of the world might be responsible for the spread and development of AMDR [78-80].
The researchers said that they hope to adapt the iPSC-derived liver cells to scalable, high-throughput culture formats to support fast, efficient antimalarial drug screens.
The basic of ligand properties docking results energy calculations and drug score favor indicated that the new antimalarial drug compound have potential to show better efficacy than pyrimethamine.
Iqbal et al., "Novel antimalarial drug targets: hope for new antimalarial drugs," Expert Review of Clinical Pharmacology, vol.
[1-3] Malaria case management encompasses prompt and effective treatment to minimise morbidity and mortality, reduce transmission and prevent the emergence and spread of antimalarial drug resistance.
For optimal function of Antimalarial drug in bioavailibilitas conditions, the solvent must be considered.
"Antimalarial drug resistance is one of the greatest challenges to continued success in controlling and eliminating malaria in the Asia?Pacific," stated Dr.