antimetabolite


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Related to antimetabolite: methotrexate

antimetabolite:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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antimetabolite

[¦an·tē·mə′tab·ə‚līt]
(pharmacology)
A substance, such as sulfanilamide or amethopterin, that inhibits utilization of an essential metabolite because it is an analog of the metabolite.
References in periodicals archive ?
A large prospective study of 215 patients with malignancy who had 317 total neutropenic episodes showed that 72.7% of patients with NE were on antimetabolites, 72.7% were on anthracyclines, and 36.4% were on alkylating agents [3].
The recommended initial measure is the reduction of immunosuppression, which was performed in 100% of the patients we reported here and which consisted of anticalcineurin suspension in all of them, and antimetabolite in the majority, with change to everolimus or sirolimus.
A successful case of trabeculectomy without adjunctive antimetabolites performed with retrobulbar anesthesia has been reported in a pregnant patient.
Low-dose antimetabolite therapy is often administered concomitantly to prevent antichimeric antibody production.
This study provides a new understanding of an unexplored antimetabolite, L-CAV as an alternative of classical antimetabolites, such as 5-fluoruracil and methotrexate.
Immunosuppressive therapy before and after RALP N = 12 Before RALP After RALP A: Calcineurin inhibitors 11/12 * (91.7%) 7/12 (58.3%) (Prograf, Advagraf) B: Corticosteroids 5/12 (41.7%) 4/12 (33.3%) C: Antimetabolite 10/12 (83.3%) 6/12 (50%) (Cellcept) D: mTor inhibitors 0/12 (0%) 8/12 * (66.7%) (Rapamune, Certican) RALP: robot-assisted laparoscopic radical prostatectomy; mTOR: mammalian target of rapamycin.
However similar results may not be obtainable in higher risk eyes without the use of antimetabolites as the only demonstrable risk factor for failure in our patients was the prior use of topical medications.
Bioisosteric replacement of carbonyl oxygen in hypoxanthine by S gives 6-mercaptopurine, a potent anticancer antimetabolite [4, 45].
The first step is a 50% decrease in the dose of the antimetabolite drug.
In this study, in which treatment with adalimumab was given for a mean of 2 years, at the end of the follow-up, only 4 patients remained on adalimumab monotherapy and the rest were on combined therapy with prednisone, methotrexate, cyclosporine A, or other antimetabolite drugs.