antimetabolite


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Related to antimetabolite: methotrexate

antimetabolite:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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antimetabolite

[¦an·tē·mə′tab·ə‚līt]
(pharmacology)
A substance, such as sulfanilamide or amethopterin, that inhibits utilization of an essential metabolite because it is an analog of the metabolite.
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A large prospective study of 215 patients with malignancy who had 317 total neutropenic episodes showed that 72.7% of patients with NE were on antimetabolites, 72.7% were on anthracyclines, and 36.4% were on alkylating agents [3].
Neutropenic Enterocolitis in a Pediatric Heart Transplant Recipient on Multiple Immunosuppressants
The recommended initial measure is the reduction of immunosuppression, which was performed in 100% of the patients we reported here and which consisted of anticalcineurin suspension in all of them, and antimetabolite in the majority, with change to everolimus or sirolimus.
Tratamiento de la enfermedad linfoproliferativa post-trasplante renal con rituximab y conversion a inhibidor m-TOR
A successful case of trabeculectomy without adjunctive antimetabolites performed with retrobulbar anesthesia has been reported in a pregnant patient.
Glaucoma surgery in pregnancy: a case series and literature review
Low-dose antimetabolite therapy is often administered concomitantly to prevent antichimeric antibody production.
Treatment of juvenile idiopathic arthritis-associated uveitis
This study provides a new understanding of an unexplored antimetabolite, L-CAV as an alternative of classical antimetabolites, such as 5-fluoruracil and methotrexate.
Cytotoxic potentiation of vinblastine and paclitaxel by L-canavanine in human cervical cancer and hepatocellular carcinoma cells
Immunosuppressive therapy before and after RALP N = 12 Before RALP After RALP A: Calcineurin inhibitors 11/12 * (91.7%) 7/12 (58.3%) (Prograf, Advagraf) B: Corticosteroids 5/12 (41.7%) 4/12 (33.3%) C: Antimetabolite 10/12 (83.3%) 6/12 (50%) (Cellcept) D: mTor inhibitors 0/12 (0%) 8/12 * (66.7%) (Rapamune, Certican) RALP: robot-assisted laparoscopic radical prostatectomy; mTOR: mammalian target of rapamycin.
Technical feasibility of robot-assisted laparoscopic radical prostatectomy in renal transplant recipients: results of a series of 12 consecutive cases
However similar results may not be obtainable in higher risk eyes without the use of antimetabolites as the only demonstrable risk factor for failure in our patients was the prior use of topical medications.
Comparison of long term intraocular pressure control following small flap vs conventional trabeculectomy
Bioisosteric replacement of carbonyl oxygen in hypoxanthine by S gives 6-mercaptopurine, a potent anticancer antimetabolite [4, 45].
Input of Isosteric and Bioisosteric Approach in Drug Design
The first step is a 50% decrease in the dose of the antimetabolite drug.
Adjuvant ciprofloxacin for persistent BK polyomavirus infection in kidney transplant recipients
In this study, in which treatment with adalimumab was given for a mean of 2 years, at the end of the follow-up, only 4 patients remained on adalimumab monotherapy and the rest were on combined therapy with prednisone, methotrexate, cyclosporine A, or other antimetabolite drugs.
Usefulness of adalimumab in the treatment of refractory uveitis associated with juvenile idiopathic arthritis
The antimetabolite 5FU is often linked with kidney damage (9).
Effects on hepatic and renal biomarkers in patients of colorectal carcinoma treated with two different schedules of 5FU/LV
Cytarabine is a cell cycle-specific (S phase) antimetabolite that inhibits DNA synthesis.
Corneal epithelial microcysts due to high-dose cytarabine administration in a pediatric acute myeloid leukemia patient / Pediatrik Akut Miyeloid Losemili Hastada Yuksek Doz Sitarabin Uygulamasina Bagli Korneal Epitel Mikrokistler

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