antimetabolite

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Related to antimetabolite: methotrexate

antimetabolite:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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antimetabolite

[¦an·tē·mə′tab·ə‚līt]

(pharmacology)

A substance, such as sulfanilamide or amethopterin, that inhibits utilization of an essential metabolite because it is an analog of the metabolite.

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Besides corticosteroids, long-term treatment options for the treatment of JIA-associated uveitis include antimetabolites, alkylating agents and biologic agents.

Treatment of juvenile idiopathic arthritis-associated uveitis

Arginine antimetabolite L-canavanine induces apoptotic cell death in human Jurkat T cells via caspase-3 activation regulated by Bcl-2 or Bd-xL.

Cytotoxic potentiation of vinblastine and paclitaxel by L-canavanine in human cervical cancer and hepatocellular carcinoma cells

However similar results may not be obtainable in higher risk eyes without the use of antimetabolites as the only demonstrable risk factor for failure in our patients was the prior use of topical medications.

Comparison of long term intraocular pressure control following small flap vs conventional trabeculectomy

Topical 5-FU is an antineoplastic antimetabolite that is applied twice daily to the lesion.

Skin cancer: a role for Rx

Eisai/Johnson & Johnson's Dacogen (decitabine) and Celgene/Nippon Shinyaku's Vidaza (azacitidine) are antimetabolite cytotoxic agents approved in the US for myelodysplastic syndromes (MDS), a type of blood cancer that can progress to leukaemia.

Cytotoxic therapies to feel the sting of generics: cytotoxic therapy, or chemotherapy as it is commonly known, has been the cornerstone of cancer treatment for many years and involves the use of drugs that are toxic to all cells--including those that are perfectly healthy. While relatively effective, this leads to the unpleasant side-effects commonly associated with cytotoxic treatment, such as vomiting, nausea, alopecia and fatigue

One-quarter had received antimetabolite therapy in the past.

Methotrexate failed to boost infliximab's benefit in Crohn's

Methotrexate is an antimetabolite that penetrates the blood brain barrier when given in high doses intravenously.

High-dose methotrexate and primary central nervous system lymphoma

Prospective, randomized, controlled trials are currently underway to formulate evidence-based algorithms for the initiation of antimetabolite therapy in IBD.

Thiopurine methyltransferase activity is correlated with azathioprine metabolite levels in patients with inflammatory bowel disease in clinical gastroenterology practice

It compared the continuation of cyclophosphamide after disease remission to "step-down" to an antimetabolite with fewer side effects, azathioprine.

Treatment of ANCA-associated systemic vasculitis

The list of other associated adverse health effects include: (a) antimetabolite affecting every organ; (b) endocrine disruptor; (c) increased risk of diabetes mellitus; (d) neurotoxicity: (e) hyperkeratosis; (f) skin pigmentation; (g) hepatotoxictiy; (h) cardiovascular disease; (i) peripheral vascular disease; and (j) diminished hearing (American Academy of Pediatrics [AAP], 2003; Centeno et al.

Letter regarding "Arsenic in a Child's World"

ALLs with hyperdiploidy with >50 chromosomes in children are highly sensitive to antimetabolite drugs and have a complete remission rate approaching 100% with an ~80% long-term disease-free survival (9).

Multifaceted approach to the diagnosis and classification of acute leukemias

Azathioprine is the generic equivalent to Imuran, an immunosuppressive antimetabolite manufactured by Glaxo Wellcome Inc.