Till now, trabeculectomy is still the most efficient option for those with progressive glaucoma. Cicatrix is the major cause of postoperative bleb failure and significantly affects the long-term success rate of trabeculectomy.,,, The use of antimitotic agents
such as 5-fluorouracil and mitomycin C (MMC) has been widely accepted as the golden standard of trabeculectomy, apparently reducing the incidence of scar formation and enhancing bleb surviving rate.
Diabetes, renal failure, duration of stent placement, small reference vessel diameter, complex lesions, low ejection fraction, local hypersensitivity reactions, position of the stent relative to plaque, type and dose of antimitotic agent
have also been identified as contributory factors (8,10-13).
The alkaloid and antimitotic agent
colchicine has shown mixed effects on the progression of fibrosis, ascites, esophageal varices, portal vein pressure, functional status, and mortality in cirrhosis patients, but no studies had assessed its effect against HCC, the investigators said.
. More rapid onset of action than imiquimod; generally requires 4 weeks of use.
Pyridine derivatives have also showed a broad spectrum of biological activities such as antimitotic agents
, anti-inflammatory substances , and anticonvulsants .
, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to prevent postsurgical scarring and improve surgical outcomes.