Therefore, rich experience in antimitotic drug
usage of ophthalmologist and prudent attitude are in great need which would increase difficulties in surgical technique learning.
Although colchicine is a powerful antimitotic drug
, it may result in severe adverse effects due to its broad biological role and high toxicity.
(2006) observed that prolonged exposure to antimitotic drugs
generated a greater number of cells with changes in the chromosome number.
Lobert, "Physiochemical aspects of tubulin-interacting antimitotic drugs
," Current Pharmaceutical Design, vol.
Based on the obtained results and previous studies can be concluded that such effects of antimitotic drugs
(cytotoxic) could include:
In a prospective single-blind, randomized clinical trial by Bassak and Chatterjee,7 it was demonstrated that oral colchicine (2 mg/day for 8 weeks) is effective for chronic plaque psoriasis, which supported the earlier study by Wahba and Cohen.8 They recommended oral colchicine in recalcitrant chronic plaque psoriasis prior to considering other potentially harmful antimitotic drugs
.7,8 The current study was designed to see the efficacy and safety of oral colchicine in the treatment of plaque psoriasis comparing with methotrexate.
Given their primary role in mitosis, microtubules have been an important target for anticancer drugs -- often referred to as antimitotic drugs
, tubulin inhibitors and microtubule targeting agents.