Although colchicine is a powerful antimitotic drug
, it may result in severe adverse effects due to its broad biological role and high toxicity.
Balloons for the prevention and treatment of restenosis antimitotic drug
2006) observed that prolonged exposure to antimitotic drugs
generated a greater number of cells with changes in the chromosome number.
The benzofuroindoline core is a unique motif found in the natural products diazonamide A, a very potent anti-cancer agent ( 5 nM against various cell lines) which may have clinical utility for cancer therapy since it is as active as widespread used antimitotic drugs
without their overt toxicity.
The patients with scarring alopecia, congenital alopecia, hair shaft disorders, abnormal thyroid function tests, any gross (clinically evident) systemic disease, ESR of more than 30mm 1st hour, postmenopausal women, patients who had taken iron, vitamin B12, folic acid or multivitamin supplements for at least 3 months before inclusion in the study, who had pregnancy in the preceding 1 year and patients on anticoagulants, antithyroid drugs, antimitotic drugs
, and oral contraceptives were excluded from the study.
Based on the obtained results and previous studies can be concluded that such effects of antimitotic drugs
(cytotoxic) could include:
Given their primary role in mitosis, microtubules have been an important target for anticancer drugs -- often referred to as antimitotic drugs
, tubulin inhibitors and microtubule targeting agents.
Approximately 20% to 30% of the intermediate filament population is resistant, even when treated with colchicine or other antimitotic drugs