Illusions of safety: antimutagens
can be mutagens, and anticarcinogens can be carcinogens.
Plant-derived products as antimutagens
. Phytotherapy Research 12(6): 389-399.
Among these, the [TABULAR DATA FOR TABLE III OMITTED] major component vitamin C, due to its antioxidant and chelating effects, has been already observed to act as anticarcinogen, antimutagen
, and anticlastogen, respectively, in different test systems (Mirvish, 1975; Parshad et al., 1978; Gebhart et al., 1985; Ginter et al., 1989).
Jain et al., "Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones--part II: mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen
7,8-diacetoxy-4-methylcoumarin," Bioorganic and Medicinal Chemistry, vol.
Potential antigenotoxic and antimutagen
activities have been reported.
Chlorophyllin: a potent antimutagen
against environmental and dietary complex mixtures.
Galangin was the most active antimutagen
among the flavonoids tested such as chrysin, tectochrysin, chrysin-5-methylether, galangin, galangin-S-methylether, pinocembrin, pinobanksin, apigenin and isalpinin.
Resveratrol was found to act as an antioxidant and antimutagen
and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity).
Chlorophyllin (CHL) is a potent antimutagen
in vitro, an effective anti-carcinogen in several animal models, and significantly reduced urinary biomarkers of aflatoxin B(1) (AFB(1)) exposure in a human population.
Most of the polymeric tannins exerting an antimutagen
activity on 2-Aminoanthracene and other nitroaromatic indirect-acting mutagens, can be classified as blocking agents since they inhibit the conversion of the latter to ultimate carcinogens.
Key words: Antimutagen
, Anticarcinogen, Phyllanthus amarus, Plant, Alkaline elution, Mutation assay
Bhattacharya, "Natural antimutagens
: A review," Research Journal of Medicinal Plant, vol.