antioncogene


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antioncogene

[¦an·tē′aŋ·kə‚jēn]
(genetics)
Any of a class of genes that are involved in the negative regulation of normal growth; the loss or mutation of these genes leads to malignant growth. More generally called tumor suppressor gene.
References in periodicals archive ?
miR-21 decreases the expression of PTEN which is an antioncogene negatively regulating the PI3K/AKT pathway and positively p53.
Accumulating facts have demonstrated that altered expression of miRNAs in human malignancies results in the deregulation of the levels of oncogenes and antioncogenes, which promotes the proliferation of cancers.
The programme content includes introduction and classifications of cancer, oncogenes, antioncogenes or Tumor suppressor genes, cancer epigenetic and regulation of oncognesis, analysis of genomic data and diet and cancer.