antisense


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Related to antisense: Antisense strand, Antisense drugs

antisense,

DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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). Antisense techniques are used to deactivate disease-causing or undesirable genes so that they cannot produce harmful or unwanted proteins. (Conventional drugs bind directly with disease-causing protein molecules, but their imperfect specificity may lead them to bind with other protein molecules, resulting in unwanted side effects. Antisense molecules are extremely specific.) In some applications of this technique, the antisense nucleic acid segment is inserted into an inactivated or nonvirulent virus, then introduced into the cell. The antisense segment pairs with the mRNA, preventing the synthesis of protein by the mRNA. Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. See also gene therapygene therapy,
the use of genes and the techniques of genetic engineering in the treatment of a genetic disorder or chronic disease. There are many techniques of gene therapy, all of them still in experimental stages.
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.

antisense

[¦an·tē′sens]
(genetics)
A strand of deoxyribonucleic acid having a sequence identical to messenger ribonucleic acid.
References in periodicals archive ?
The OncoGenex and Isis partnership combines OncoGenex' proprietary antisense position in inhibitors to the target, clusterin, with Isis' proprietary second-generation antisense chemistry called 2'-O-methoxyethyl.
The promise of antisense drugs lies in the theory that they work on a specific target disease without causing significant side effects.
Under the terms of the agreement, AVI is granting Eleos an exclusive license to AVI's NEUGENE([R]) third-generation antisense chemistry to treat cancer with p53-related drugs.
ATL1101 is a second-generation antisense drug designed to block the synthesis of the IGF-1 receptor, a protein involved in the regulation of cell overgrowth in psoriasis.
However, even though they gave higher doses of the antisense material to some patients, the researchers have not yet achieved a high enough concentration of this drug in the blood.
This partnership with DTRA and the DoD serves as validation of AVI's proprietary NEUGENE([R]) antisense approach to gene silencing in general, as well as specific confirmation of AVI's concept of rapid response therapeutics," said Alan P.
The Canadian patent application covers Enzo's pioneering technology for antisense RNA.
Like DNA, antisense molecules carry much more information than a typical drug molecule, says Stanley T.
Nasdaq:AVII), today announced human clinical trial results showing that three distinct NEUGENE([R]) antisense drugs entered the cerebral spinal fluid (CSF) of healthy adult male volunteers following a single 100 mg dose via intravenous (IV) or subcutaneous (subq) injections.
Antisense genetics is more than just a tool for customizing tomatoes.
For the published study, eight NEUGENE antisense agents were evaluated for their ability to inhibit influenza A virus by blocking the complementary RNA sequences that are highly conserved across viral subtypes.
Rosenberg of the Massachusetts Institute of Technology in Cambridge, used antisense to prevent arterial thickening among rats whose neck arteries had been reamed by balloon angioplasty Rosenberg, who also holds a post at the Harvard Medical School's Beth Israel Hospital in Boston, and his colleagues report their results in the Sept.