antisense


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Related to antisense: Antisense strand, Antisense drugs

antisense,

DNA or RNA manipulated in a laboratory so that its components (nucleotides) form a complementary copy of normal, or "sense," messenger RNA (mRNA; see nucleic acidnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
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). Antisense techniques are used to deactivate disease-causing or undesirable genes so that they cannot produce harmful or unwanted proteins. (Conventional drugs bind directly with disease-causing protein molecules, but their imperfect specificity may lead them to bind with other protein molecules, resulting in unwanted side effects. Antisense molecules are extremely specific.) In some applications of this technique, the antisense nucleic acid segment is inserted into an inactivated or nonvirulent virus, then introduced into the cell. The antisense segment pairs with the mRNA, preventing the synthesis of protein by the mRNA. Antisense has applications in agricultural biotechnology, where it has been used to deactivate the gene that causes softening in tomatoes, and in medicine, especially in cancer and antiviral therapy. See also gene therapygene therapy,
the use of genes and the techniques of genetic engineering in the treatment of a genetic disorder or chronic disease. There are many techniques of gene therapy, all of them still in experimental stages.
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.

antisense

[¦an·tē′sens]
(genetics)
A strand of deoxyribonucleic acid having a sequence identical to messenger ribonucleic acid.
References in periodicals archive ?
I am committed to ensuring that Ionis continues to advance these important medicines and our antisense platform, while continuing to build on the company's financial strength, so that we can continue to provide great benefit to even more patients and to our shareholders.
The product is a first in class unmodified antisense oligodeoxynucleotide that inhibits a cell membrane hemichannel forming protein, connexin43 (Cx43).
In this collaboration, Ionis will be responsible for the identification of antisense drug candidates based on selected targets, while Biogen will be responsible for and pay for non-clinical studies, clinical development, manufacturing, and commercialization.
"We are committed to advancing new RNA-targeted therapeutics, like RNAi and antisense, to patients with high unmet medical need in China," said Liang Zicai, founder and chairman of Ribo.
Advances in RNAi, Antisense, and Non-Coding RNA-Based Drugs in Clinical Development
She said that their current findings suggest that the compound, which is called antisense oligonucleotide (OL-1), is a potential treatment for Alzheimer's disease.
For this purpose, in addition to the investigated wild type tomato, two homozygous independent antisense transgenic tomato lines (Sl-ERF.B.3.AS42 and Sl-ERF.B.3.AS38) (provided by the Laboratory of Genomic and Fruit Biotechnology, UMR990 INRA/INP-ENSA Toulouse, France) were included in this part of our study.
The collaboration combines Isis' antisense expertise with Roche's expertise in developing neurodegenerative therapeutics.
Mice that were given the antisense compounds twice a week for four weeks had reduced symptoms for up to one year, according to the paper.
Indeed, U7.623 antisense is already confirmed for its effectiveness in repairing gene therapy for several beta-thalassemia mutations [5-8].
Isis Pharmaceuticals, (Nasdaq: ISIS) and its collaborators have presented results on the antisense inhibition of novel targets that could offer new mechanisms to treat cancer during the American Association for Cancer Research (AACR) meeting.
Research progress in antisense elements (genetics).