ISIS-SOD1Rx, which targets the best understood genetic cause of familial ALS, is the first
antisense drug to treat ALS to enter clinical development under the strategic collaboration between Isis and Biogen.
The patent claims broadly cover
antisense drugs with "chimeric" or "gapmer" structures, including Isis' proprietary second-generation structures and the compositions of numerous other antisense compounds.
Lilly has several
antisense drug candidates derived from the collaboration that are in or approaching clinical trials.
will describe his team's early data on human trials with another
antisense drug -- one that attacks HIV, the virus that causes AIDS.
The company has successfully commercialized the world's first
antisense drug and has 11
antisense drugs in development to treat metabolic, cardiovascular and inflammatory diseases, and cancer.
The company has successfully commercialized the world's first
antisense drug and has 12
antisense drugs in development to treat metabolic, cardiovascular and
The collaboration with GSK has been very productive and has resulted in a number of novel
antisense drugs in its pipeline to treat a diverse range of diseases, concluded B.
We are pleased to have made considerable progress in our
antisense drug discovery collaboration with Amgen," said Brett P.
Drug development company Isis Pharmaceuticals Inc (Nasdaq:ISIS) and Xenon Pharmaceuticals Inc, a clinical genetics-based drug discovery and development company, announced today that Xenon has exercised its option to an exclusive worldwide license to XEN701, an
antisense drug discovered in a collaboration between Isis and Xenon.
M2 EQUITYBITES-June 10, 2013-Isis licenses
antisense drug XEN701 to Xenon for USD2.
We're hoping to get our [bcl-2]
antisense drug into clinical trials soon," says Reed.
Researchers concede that, depending on how things go, five years or more may pass before final FDA approval of the first
antisense drug.
