antithrombin


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Related to antithrombin: heparin, Antithrombin deficiency

antithrombin

[‚an·tē′thräm·bən]
(biochemistry)
A substance in blood plasma that inactivates thrombin.
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References in periodicals archive ?
Antithrombin III activity was found to be lower in the patient group compared to that of the control group (p=0.001).
(3) However, a meta-analysis on thrombophilia in PVT showed a prevalence of antithrombin deficiency (3.9%), protein C deficiency (5.6%), and protein S deficiency (2.6%), with odds ratios of 8.89, 17.63, and 8.00, respectively.
Name the antithrombin heparin binding site methods that have been used.
(2012) Thrombosis from a prothrombin mutation conveying antithrombin resistance.
Among its disadvantages, anti-Xa assay does not reflect all the anticoagulant properties of UFH, including prothrombin, factors IX and VIII, and antithrombin activity (Price et al., 2013; Takemoto et al., 2013).
Kinjo et al., "Impact of Antithrombin III concentrates on portal vein thrombosis after splenectomy in patients with liver cirrhosis and Hypersplenism," Annals of Surgery, vol.
Leys, "Antithrombin, protein C and protein S levels in 127 consecutive young adults with ischemic stroke," Acta Neurologica Scandinavica, vol.
Utterback et al., "Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei," International Journal of Infectious Diseases, vol.
The patient is a woman who was initially diagnosed at the age of 22 with inherited type I AT deficiency as part of a family screen, with immunological AT level of 0.52 U x [mL.sup.-1] (reference range 0.80-1.20 U x [mL.sup.-1]) and functional AT level 0.49 U x [mL.sup.-1] (reference range 0.77-1.25 U x [mL.sup.-1]) (Coamatic Antithrombin assay from Chromogenix).
Of the coagulation parameters, while prothrombin and partial thromboplastin times, protein S and factors 2, 5, 8, 9, 10 and 11, were determined as normal, antithrombin III (15.8%; normal 75-125%) and protein C (62%; normal 70-140%) were found to be low.
The aim of this study was to determine in a prolonged longitudinal study (i.e., 13 repeated blood sampling and measurements across a period of 1 year) the biological variation of hemostasis variables involved in thrombosis and bleeding [prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, antithrombin (AT), protein C, protein S, factor VIII, factor IX, von Willebrand factor (VWF)].