antithrombin

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Related to Antithrombin III: antithrombin III test, protein C

antithrombin

[‚an·tē′thräm·bən]
(biochemistry)
A substance in blood plasma that inactivates thrombin.
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Antithrombin III activity was found to be lower in the patient group compared to that of the control group (p=0.001).
Salzman, "Acute Aortic Thrombosis in Antithrombin III Deficiency," Journal of the American Medical Association, vol.
The in situ inhibition of prothrombinase-formed human alpha-thrombin and meizothrombin(des F1) by antithrombin III and heparin.
Application of Antithrombin III Is the Best Anticoagulation Strategy for Splenectomy.
Parameter Result Normal values WBC count (*[10.sup.9]/L) 8.4 4-10 Platelets count (*[10.sup.9]/L) 209 140-400 Hemoglobin (Gr%) 15.1 14-18 PT (%) 73.03 60-100 aPTT (s) 54.7 25-49 INR 1.22 1-1.4 D-DIMER (mcg/mL) 0.14 0-0.5 Factor VIII level (%) 17 70-140 Factor VIII inhibitor screening Negative Protein C activity Normal 70-120 Protein S activity Normal 70-140 Antithrombin III level Normal APC resistance Negative Lupus anticoagulant Absent Anticardiolipin antibodies Absent Factor V Leiden defect Absent Prothrombin G20210A Heterozygote ESR 28 1-20 CRP (mg%) 1.42 <0.5 ANA Absent C-ANCA (unit/mL) 8 >18 P-ANCA (unit/mL) 1.6 >18 C3 (mg/dL) 138 90-180 C4 (mg/dL) 27 10-40
During the operation it was not possible to achieve our standard target activated clotting time (ACT) for OPCAB (>250 sec), despite high doses of heparin and antithrombin III. The immediate postoperative course was characterized by an intense inflammatory response.
Of the coagulation parameters, while prothrombin and partial thromboplastin times, protein S and factors 2, 5, 8, 9, 10 and 11, were determined as normal, antithrombin III (15.8%; normal 75-125%) and protein C (62%; normal 70-140%) were found to be low.
These tests included a hypercoagulability workup including prothrombin time, partial thromboplastin time, antiphospholipid antibodies, protein C and S activity, antithrombin III activity, homocysteine level, and prothrombin F2 G20210A mutation.
Progression from moderate to severe hypoglycemia, coagulopathy, marked decrease of antithrombin III activity, encephalopathy, and frank liver failure can rapidly ensue.
Elevated plasma fibrinogen, impaired fibrinolysis with decreased level of antithrombin III, and reactive thrombocytosis favor development of DVT in pulmonary tuberculosis [6].
Antithrombin III (AT) is synthesized in liver and changes in its levels are associated with the extent of cirrhosis.
Inhibition of thrombin-neutralizing activity of antithrombin III by steroid hormones.