globulin

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Related to antithymocyte globulin: cyclosporine, Atgam, antithymocyte globulin equine

globulin,

any of a large family of proteinsprotein,
any of the group of highly complex organic compounds found in all living cells and comprising the most abundant class of all biological molecules. Protein comprises approximately 50% of cellular dry weight.
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 of a spherical or globular shape that are widely distributed throughout the plant and animal kingdoms. Many of them have been prepared in pure crystalline form. The term globulin is a partly procedural one, used in classifying an otherwise diverse group of proteins that are soluble in water or dilute salt solutions. Among the most important are the immunoglobulins (Ig), the antibodies of the immune system (see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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). They are classified into five types based upon structure: IgA, IgD, IgE, IgG, and IgM. IgG or &ggr;-globulin is the most common and forms about 70% of the immunoglobins in the blood. Other globulins are involved in the transport of a variety of substances, including lipidslipids,
a broad class of organic products found in living systems. Most are insoluble in water but soluble in nonpolar solvents. The definition excludes the mineral oils and other petroleum products obtained from fossil material.
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, hormoneshormone,
secretory substance carried from one gland or organ of the body via the bloodstream to more or less specific tissues, where it exerts some influence upon the metabolism of the target tissue.
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, and inorganic ions.

Globulin

A general name for any member of a heterogeneous group of serum proteins precipitated by 50% saturated ammonium sulfate. See Protein, Serum

The introduction of electrophoresis during the 1930s permitted subdivision of the globulins into alpha, beta, and gamma globulins on the basis of relative mobility at alkaline pH (8.6). However, each of these subgroups, though electrophoretically homogeneous, consists of a great variety of proteins with different biological properties and markedly different sizes and chemical properties other than net charge. Thus the α2-globulins, for example, as defined by moving boundary or paper electrophoresis, contain proteins ranging in molecular weight from approximately 50,000 to approximately 1,000,000 (α2-macroglobulin), each with differing functions. See Immunoglobulin

globulin

[′gläb·yə·lən]
(biochemistry)
A heat-labile serum protein precipitated by 50% saturated ammonium sulfate and soluble in dilute salt solutions.

globulin

any of a group of simple proteins, including gamma globulin, that are generally insoluble in water but soluble in salt solutions and coagulated by heat
References in periodicals archive ?
Prospective randomized multicenter study comparing cyclosporine alone versus the combination of antithymocyte globulin and cyclosporine for treatment of patients with nonsevere aplastic anemia: A report from the European blood and marrow transplant (EBMT) severe Aplastic working party.
Multicenter randomized study comparing cyclosporine A alone and antithymocyte globulin with prednisone for treatment of severe aplastic anemia.
In refractory cases interventions parallel those for aplastic anaemia, with significant response rates following immunosuppression, particularly with antithymocyte globulin and prednisone, and possibly in combination with anti-CD 20 monoclonal antibody, among other therapeutic possibilities.
Immunosuppressive therapy with antithymocyte globulin and cyclosporine for prolonged marrow failure after hemophagocytic syndrome.
All Class III patients received conditioning regimen as per Pesaro Protocol 26 and antithymocyte globulin (ATG) except one patient who had received Pesaro Protocol 26 without ATG.
Allogenic HSCT was performed in August 2006 after conditioning with total body irradiation (200 cGy, day -8 before HSCT surgery), fludarabine (days -7 to -4), antithymocyte globulin (days -4 to -1), and cyclophosphamide (days -3 to -2).
Antithymocyte globulin may also have a role in therapy (60).
The conditioning regimen for the transplant consisted of busulfan, cyclophosphamid, and antithymocyte globulin administered with a Hickman catheter.
On the basis of the immunologic pathophysiology of familial HLH, a combination of antithymocyte globulins with corticosteroids, cyclosporin A, and intrathecal injections of methotrexate is indicated7.