In the present study, rifampicin is used as a model antitubercular agent
. The main objective of the present study was to formulate and optimize oral sustained release Chitosan nanoparticles of Rifampicin by design of experiment (DOE).
This plant has been used as a folklore medicine for anti-inflammatory and anti-arthritic effects, and also used as antitubercular agent
by Miao people.
In recent years, a number of researchers have been trying to develop novel antitubercular agents
targeting conserved protein targets.
Peoples, Isonicotinyl hydrazones as antitubercular agents
and derivatives for identification of aldehydes and ketones, J.
Based on the MDR and antitubercular activities of 2-substituted benzothiazoles, it appears that this backbone is an excellent lead compound for the development of novel antitubercular agents
. It has been confirmed that there is an increase in hydrophobicity of the [OCH.sub.3] group at the C-4 position of the phenyl ring, which is attached to the azetidinone nucleus, which results in an increase in the antitubercular potency.
KEYWORDS: Antitubercular agents
, Mycobacterium infection, Interstitial lung diseases.
Fifty molecules of 1,2,4-Triazole derivatives as potent antitubercular agents
that were used in this study were obtained from the literature .
formulated a niosomal drug delivery system of antitubercular agents
such as isoniazid that has exceptional potential for development into a low dose performed with effective treatment for tuberculosis .
Although we thought of a wide variety of infections as differential diagnoses, we strongly suspected leptospirosis on the basis of severe acute respiratory failure, myocardial pericarditis, renal failure, jaundice, and thrombocytopenia, which made us continue the broad-spectrum antibiotics, levofloxacin, vancomycin, meropenem, antitubercular agents
, and add benzylpenicillin.
The various study tools used were the patient profile form which recorded all the information, such as name, age, sex, socioeconomic status, life style factors and dietary factors and any concurrent diseases and medications other than antitubercular agents
that the patients might be taking.
Hence, in continuation to our efforts [22-67] in developing QSAR studies for angiotensin II AT: receptor, antitubercular agents
, antimalarial activity, antimicrobial activity, antibacterial activity, COX inhibitors, and so forth.
Bijev, "New heterocyclic hydrazones in the search for antitubercular agents
: synthesis and in vitro evaluations," Letters in Drug Design and Discovery, vol.