Antituberculotic


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Antituberculotic

 

a medicinal preparation that has a specific effect on the pathogen of tuberculosis. There are two groups of antituberculotics: principal antituberculotics and reserve antituberculotics.

Principal antituberculotics include isoniazid; hydrazide of isonicotinic acid and its derivatives, including Phthivazid, Methazid, saluzid, and Larusan; antibiotics, including streptomycin sulfate and dihydrostreptomycin sulfate; and sodium of para-aminosalicylic acid (PAS), BEPASC (benzacyl), and Pasomycin, which consists of dihydrostreptomycin in combination with PAS.

Reserve antituberculotics are used mainly to act on the mycobacteria of tuberculosis that have become resistant to preparations of the first group. They include antibiotics, for example, kanamycin, phaoromycin, and cycloserine, and such preparations as ethionamide, protionamide, pyrazinamide, ethoxyde, and tibione.

The antituberculotics rifampicin and ethambutol were created in the 1960’s. They are used in chronic forms of tuberculosis that have not responded to prolonged therapy with preparations of the first and second groups and in cases when other antituberculotics are not tolerated.

REFERENCES

Shebanov, F. V. Tuberkulez. Moscow, 1969.
Rabukhin, A. E. Khimioterapiia bol’nykh tuberkulezom. Moscow, 1970.

F. V. SHEBANOV