Various clinical presentations of AOS include oligohydramnios, cutis marmorata, upper limb micromelia and brachypodia, acrania, microcephaly, palatine or auricular malformations, intracranial calcifications, hydrocephaly, arhinencephaly, spina bifida, epilepsy, mental retardation, anatomic bronchial anomalies, renal abnormalities, and cardiovascular anomalies such as bicuspid aortic valve, atrial septal defect, Shone's complex, aortic valve stenosis, hypoplastic left heart syndrome, tetralogy of Fallot, double outlet right ventricle, portal hypertension and pulmonary hypertension.11,12 Our patient had cutis marmorata telangiectatica, aplasia cutis congenita
, and terminal transverse limb reduction defects.
SCALP###The coincidence of sebaceous nevus syndrome, central nervous system malformations, aplasia cutis congenita
, limbal dermoid, and pigmented nevus (giant congenital melanocytic nevus).23
Infected infants are often pre mature, and typically present with evidence of chronic infection, atrophy, and scars suggestive of epidermolysis bullosa or aplasia cutis congenita
. A high index of suspicion and the above studies for HSV are needed to confirm the diagnosis.