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Related to aplastic crisis: aplastic anemia, sequestration crisis


Pathol a sudden change, for better or worse, in the course of a disease
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a sharp turning point in the course of a disease that is accompanied by a drop in elevated body temperature and improvement in the patient’s condition.

A crisis usually occurs in acute-onset diseases with a rapid rise in temperature (croupous inflammation of the lungs, malaria, relapsing fever, and so forth). A crisis is associated with profuse sweating, marked weakness, and sometimes a temporary slowing of cardiac activity. A crisis is the opposite of a gradual subsidence of a pathological process and lowering in temperature called lysis. A crisis is to be distinguished from a pseudocrisis, in which there is only a temporary lowering of temperature and improvement in the patient’s condition. A critical drop in temperature may also occur as a result of removal of the suppurative focus from the patient’s body or administration of powerful antimicrobial agents.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


The turning point in the course of a disease.
The psychological events associated with a specific stage of life, as an identity crisis or developmental crisis.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Aplastic crisis in sickle cell anemia; a study of its mechanism and its relationship to other types of hemolytic crises.
One of the theories behind the etiology of transient pancytopenia in HPV B19 infections is that the virus could be responsible for the temporary arrest of hematopoiesis that leads to aplastic crisis in persons with chronic hemolytic anemia.
HPV B19 induced aplastic crisis in a family leading to the diagnosis of hereditary HS is a very rare reported event in the literature.
Although transient aplastic crisis is self-limited, red cell transfusion as a supportive treatment should be provided in case of acute anemia.
In sickle cell anemia, erythrocyte membrane defects, red cell enzyme defects, thalassemia, and acquired hemolytic anemia result in stressed erythrocyte production as in hemorrhage, iron deficiency anemia and bone marrow transplantation, in which there may be a red cell hemolytic process, and the preceding PV infection can present with transient aplastic crisis (38), (39), (47).
The virus is strongly associated with erythema infectiosum (fifth disease), the transient aplastic crisis observed in patients with hemolytic anemia, arthropathy, and fetal wastage.
Aplastic crisis. Patients with hematologic problems that are associated with a high RBC turnover rate are at risk for developing a transient aplastic crisis when infected with parvovirus B19 (Gillette, 1993).
A child with aplastic crisis may appear pale and be tired and less active than usual.